echemi logo
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > Science challenges conventional wisdom: How calorie restriction affects the body

    Science challenges conventional wisdom: How calorie restriction affects the body

    • Last Update: 2022-03-07
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit

    Calorie restriction can prolong the lifespan of animals and reduce the burden of disease

    By combining human and mouse studies, the authors have identified a promising protein to target

    Evidence has long shown that calorie restriction can extend the lifespan of lab animals, and some people tout measures such as intermittent fasting in an attempt to achieve something similar

    "One of the most significant and very positive effects was on the thymus," Dixit said

    He and his team took a deeper look at how calorie restriction affects the body

    In response to caloric restriction, one gene that is expressed at lower levels is pla2g7—specifically in immune cells called macrophages, which are essential for maintaining fat tissue function but also cause inflammation

    To find the link between the gene and the effects of calorie restriction, the researchers knocked out the PLA2G7 gene in mice

    Excitingly, new work by Dixit et al using CALERIE samples and MRI scans shows that compared to controls, the thymus.

    Mittelbrunn said she would like to see further research into PLA2G7 as a regulator of how long mice survive and stay healthy

    Calorie reduction may also mediate its effects through other molecules, says Dixit, whose team is investigating several candidate molecules


    Caloric restriction in humans reveals immunometabolic regulators of health span

    This article is an English version of an article which is originally in the Chinese language on and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to with relevant evidence.