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    Home > Biochemistry News > Biotechnology News > Science challenges conventional wisdom: How calorie restriction affects the body

    Science challenges conventional wisdom: How calorie restriction affects the body

    • Last Update: 2022-03-07
    • Source: Internet
    • Author: User
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    Calorie restriction can prolong the lifespan of animals and reduce the burden of disease


    By combining human and mouse studies, the authors have identified a promising protein to target


    Evidence has long shown that calorie restriction can extend the lifespan of lab animals, and some people tout measures such as intermittent fasting in an attempt to achieve something similar


    "One of the most significant and very positive effects was on the thymus," Dixit said


    He and his team took a deeper look at how calorie restriction affects the body


    In response to caloric restriction, one gene that is expressed at lower levels is pla2g7—specifically in immune cells called macrophages, which are essential for maintaining fat tissue function but also cause inflammation


    To find the link between the gene and the effects of calorie restriction, the researchers knocked out the PLA2G7 gene in mice


    Excitingly, new work by Dixit et al using CALERIE samples and MRI scans shows that compared to controls, the thymus.


    Mittelbrunn said she would like to see further research into PLA2G7 as a regulator of how long mice survive and stay healthy


    Calorie reduction may also mediate its effects through other molecules, says Dixit, whose team is investigating several candidate molecules


    references:

    Caloric restriction in humans reveals immunometabolic regulators of health span

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