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Science cover article: Generating CAR-T cells in vivo to treat heart damage

 Last Update: 2022-01-26
 Source: Internet
 Author: User

Preparation of CAR-T cells in vivo

Cardiac fibrosis is fatal

Rurick et alAn immunotherapy strategy was designed to generate transient chimeric antigen receptor (CAR) T cells capable of recognizing cardiac fibrotic cells (see Gao and Chen)

We have developed a therapeutic approach to generate transient anti-fibrotic chimeric antigen receptor (CAR) T cells in vivo by delivering modified messenger RNA (mRNA) in T cell-targeting lipid nanoparticles (LNPs)

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