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    Home > Science: CRISPR gene editing technology can also be applied to RNA

    Science: CRISPR gene editing technology can also be applied to RNA

    • Last Update: 2017-10-30
    • Source: Internet
    • Author: User
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    The therapeutic potential of CRISPR / CAS genomic editing tools is growing as US scientists have developed new versions of the system that can target RNA and chemically alter its nucleotides As RNA is eventually translated into proteins, being able to clip it is good for studying genes and developing gene therapy methods, Zhang said He led research teams at the Bode Institute and MIT to conduct in-depth research on CRISPR technology Characterization of highly active cas13b for RNA modification (source: Science) he said: "many genes can play different roles according to the time and place of expression By regulating at the RNA level, we can start to try to understand these different roles RNA editing technology also has great potential as a therapeutic tool because of its ability to regulate DNA management Zhang and his colleagues developed a system that uses a bacterial enzyme called cas-13 to modify messenger RNA (mRNA) in cells, much like the way cas-9 uses to recognize and cut DNA Instead of using cas-13 to change RNA, however, a "dead" version was created that could still target RNA but had no catalytic activity They fuse it with adenosine deaminase, which can convert a (adenosine) nuclear base into inosine, which is read by cells as G (guanosine) To measure the sequence flexibility of repairv1 for RNA editing (source: Science) by combining it with the target complementary guide RNA, they designed a system called RNA editing technology, which is used to replace or repair programmable A to I, and can target specific mRNA transcripts "There is a mismatch in the specific design of the guiding RNA at the target site, as opposed to the adenosine to be edited," Zhang explained "This mismatch works on [adenosine deaminase], allowing precise editing of the target a site He added: "repair enables precise and efficient single base changes within RNA transcripts It's like using find and replace in a word processor to correct typos Helen O'Neill, a molecular geneticist at University College London, UK, who represents the specificity of repairv1 (source: Science), said that the technology paved the way for selective and time-specific regulation of gene output "Potentially, manipulating RNA will face fewer ethical problems than editing DNA, because the effects of RNA are not necessarily permanent," she added Paper link: http://science.sciencemag.org/content/early/2017/10/24/science.aaq0180 brief introduction of corresponding author: https://
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