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Science: Genome-wide analysis of somatic noncoding mutational patterns in cancer

 Last Update: 2022-05-18
 Source: Internet
 Author: User

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A key hallmark of tumor development is that cancer cells acquire somatic mutations in their genomes that are not present in normal tissues

Many statistical methods detect driver mutations as recurrent mutational events by comparing the number of mutations in each gene with and without impact on the protein-coding sequence

statistics

A genome-wide compendium of somatic mutational patterns in human cancers

In addition, these authors identified 3.

breast cancer

Taken together, the new study establishes a genome-wide compendium of distinct mutational patterns that shape the genomes of 19 major cancer types, including occurring near genes with known roles in tumor biology.

References:

Felix Dietlein et al.

Felix Dietlein et al.
Genome-wide analysis of somatic noncoding mutation patterns in cancer .
Science, 2022, doi:10.
1126/science.
abg5601.
Genome-wide analysis of somatic noncoding mutation patterns in cancer

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