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    Home > Active Ingredient News > Digestive System Information > Science: Heavy discovery! 3 kinds of intestinal bacteria "light up" 4 kinds of cancer immunotherapy.

    Science: Heavy discovery! 3 kinds of intestinal bacteria "light up" 4 kinds of cancer immunotherapy.

    • Last Update: 2020-08-30
    • Source: Internet
    • Author: User
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    Immunotherapy has been on fire for years, but clinical results have been mixed: some effective immunotherapy treatments have enhanced the immune status of cancer patients and successfully destroyed cancer cells;
    why is this? A new study has found new clues in the gut microbiome.
    , August 14 (Xinhua) -- In a new study published in Science, a team from the Cumming School of Medicine at the University of Calgary in Canada has discovered which gut bacteria can help the immune system fight cancer tumors and how they do so.
    findings give us a new understanding of the clinical outcomes of immunotherapy.
    studies have shown that combining immunotherapy with specific microorganisms enhances the immune system's ability to recognize and attack cells such as melanoma, bladder cancer, and colorectal cancer cells.
    team led by Dr. Kathy McCoy, director and lead researcher of the International Microbiology Group at Cumming School of Medicine, focuses on harnessing the power of the microbiome to improve health and treat diseases.
    to harness and guide this power, scientists need to better understand the role of bacteria in regulating the immune system, mcCoy said.
    Recent studies provide strong evidence that gut microbiomes can positively affect anti-tumor immunity and play an active role in improving the effectiveness of immunotherapy for certain cancers," she said.
    , however, how bacteria do this remains a mystery.
    we can now continue this work by showing how specific bacteria enhance the power of T-cells.
    study, the researchers isolated three types of bacteria: Bifidobacterium pseudolongum, Lactobacillus Johnsonii, and Olsenella.
    in sterile mice, the researchers introduced these special bacteria into mice with immunos checkpoint inhibitors.
    results showed that they significantly enhanced the effectiveness of immunotherapy in four mouse cancer models.
    results show that specific bacteria play an important role in immunotherapy, which causes tumors to shrink sharply.
    that immunotherapy was ineffective in mice that were not treated with beneficial bacteria.
    researchers found that intestinal prosthetic bipolios regulate and enhance the immunotherapy response by producing the metabolite myosine.
    decreased intestinal barrier function caused by immunotherapy increases the systematic transport of myosine and the activity of anti-tumor Th1 cells.
    of myosides depends on the adenosine A2A receptors expressed in T cells and requires joint stimulation.
    , lead author of the study and a senior postdoctoral researcher at McCoy Labs, said: "Myosine interacts directly with T cells and works with immunotherapy to improve treatment.
    cases, all colorectal cancer cells are destroyed.
    " researchers later confirmed the results of bladder cancer and melanoma.
    , the study identified a new microbial metabolite immune pathway that is activated by immunotherapy and can be used to develop microbial-based complementary therapies.
    McCoy says the next step will be to test it in human cancer.
    three beneficial bacteria associated with mouse tumors have also been found in human cancers.
    determine how microbes can improve immunotherapy is critical to designing treatments that have anti-cancer properties, which may include microbial therapies," said McCoy, a professor at the U.S. Government.
    microbiome is an amazing collection of billions of bacteria that live in and around us every day.
    we are still in the early stages of fully understanding them and using this new knowledge to improve the effectiveness and safety of cancer treatments, as well as survival and well-being of cancer patients.
    "
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