Science: How long will the new crown vaccine be effective?

Vaccines work because there is a kind of immune cell in our body-memory B cells.

Recently, the Scott D.

In order to study the changes of cellular immune memory in human life and across tissues, researchers performed specific immunoglobulin heavy chains (IGH) of 6 common pathogens and volunteers who had not been exposed to Ebola virus and new coronavirus virus.

Frequency, category switching and SHM of child and adult disease-specific convergent clones

B cell clones are generally divided into three categories: (1) naive clones containing only unmutated IgM or IgD (unmutM/D); (2) IgM/D with antigens, with a median SHM over 1% and no class switching members ( mutM/D); (3) Antigenic clones (CS) with class switching members.

The results of the study showed that the frequency of IGH fusion was the lowest in cord blood samples.

Distribution of fusion B cell clones in tissues

In the analysis of blood, spleen, mediastinal lymph node (MDLN) and mesenteric lymph node (MSLN) of 8 adult dead organ donors, the frequency of fusion clones of Hib, NM, PP, TT, RSV and influenza in adult lymph nodes and spleen blood.

Previous reports suggest that specific B cells against bacterial capsular polysaccharides are enriched in the spleen, and patients with splenectomy are susceptible to infection by these bacteria.

Fusion clone of SARS-CoV-2 and EBOV

In samples without COVID-19 disease or before the disease, the researchers found that SARS-CoV-2 fusion clones are more common in children's blood.

In conclusion, this article reveals that B cell memory differs from pathogen to pathogen.

Original source:

Fan Yang, et al.