SCIENCE: How viruses circumvent the immune response caused by CRISPR-Cas
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Last Update: 2020-06-24
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Source: Internet
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Author: User
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During the VI CRISPR-Cas antiviral reaction, crRNA-guided nuclease Cas13 can identify complementary viral transcripts, triggering the degradation of host and viral RNAuntil now, it is not clear how the virus will counteract this immunityRecently, researchers discovered a type of listeria (jLS46) that encodes the anti-CRISPR protein (AcrVIA1), which inactivates the VI-A CRISPR system in Listeriausing genetic, biochemical, and structural biology studies, the researchers found that AcrVIA1 interacts with cas13a's guide surface, preventing the incoming target RNA and the structural changes needed for nuclease activationDNA removal of inhibitors of Cas nuclease causes limited immunosuppression and requires multiple infections to bypass CRISPR defensesUnlike this inhibitor, a single dose of AcrVIA1 delivered by a single virus completely disrupts the vi-A CRISPR-mediated immune response
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