echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Infection > Science: Human antibodies that are powerful and SARS-CoV-2 have this "excellent" gene

    Science: Human antibodies that are powerful and SARS-CoV-2 have this "excellent" gene

    • Last Update: 2020-07-16
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    !---- The new coronavirus pneumonia (COVID-19) pandemic caused by the new coronavirus (SARS-CoV-2) has plunged the world into varying degrees of disasterso far, more than 12 million people have been infected and more than half a million people have died, and the economies of many countries have been mired in a decades-old downturnalthough several vaccines and drugs have entered the clinic, researchers do not yet know the molecular characteristics that lead to an effective antibody responseJuly 13 local time, an article published in Science revealed the key factors in the effective neutralizing of SARS-CoV-2 antibodiesA team of researchers at the Scripps Research Institute inanalyzed nearly 300 antibodies and found that all powerful neutralizing antibodies had a common antibody-coding gene, the IGHV3-53 gene"This type of antibody is often isolated in the study of COVID-19 patients, and we can now understand the structural basis of its interaction with SARS-CoV-2," said Ian Wilson, senior author of the: 10.1126 /science.abd2321 report and director of the Department of Integrated Structural and Computational Biology at the Scripps Research Institute" antibodies are Y-shaped proteins produced by immune cell B cells, each of which produces a specific type of antibody encoded by the antibody genein the study, researchers analyzed 294 different neutralizing antibodies previously isolated from the blood of rehabilitative patients and found that the IGHV3-53 gene in the heavy-chain variable region was the most common gene, encoded by about 10 percentthe distribution of The IGHV gene use of 294 antibodies targeting RBD is necessary for the virus to invade the host is the binding of the receptor binding domain (RBD) of the satchi (S) protein to the host receptor ACE2, and all effective neutralized antibodies should be able to block this binding to achieve resultsin the study, the researchers used a tool called X-ray crystallography to image two different IGHV3-53 antibodies CC12.1 and CC12.3 to understand the intrinsic molecular characteristics of IGHV3-53 strongly recognized RBD, the researchers also found that IGHV3-53 encoded antibodies contain abnormally short variants of the CDR H3 ring, which is usually a key target binding elementcompared to other antibodies not encoded by IGHV3-53, these antibodies have very strong neutrality to SARS-CoV-2the structure of the two IGHV3-53 antibodies, a small amount of antibodies encoded by IGHV3-53 are present in the human body, however, under normal circumstances, when B-cells are activated by the virus corresponding to them, they begin to multiply and cause partial mutations in the antibody gene, and as the mutationincreases increase, the more difficult it is to induce the same process with the vaccinebut fortunately, compared to the original antibodies in the healthy human blood, COVID-19 rehabilitation patients have very few antibody mutations, and still very effective in neutralizing the virus, suggesting that the vaccine may be relatively easy to induce these effective neutralizing antibodies protection response "This study provides important inspiration for the design of the effective COVID-19 vaccine," said Dr Dennis Burton, professor and co-chair of the Department of Immunology and Microbiology at Scripps Research levels of IGHV3-53 encoded antibodies may be an indirect marker of successful vaccine trials under going on and in the future
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.