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    Home > Biochemistry News > Biotechnology News > Science Immunology challenges the original theory: the mechanism of action of ineffective drugs for psoriasis

    Science Immunology challenges the original theory: the mechanism of action of ineffective drugs for psoriasis

    • Last Update: 2021-11-01
    • Source: Internet
    • Author: User
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    Picture: In inflamed skin, keratinocytes with interleukin-12 receptor (left picture) divide less than keratinocytes without this receptor (right picture)


    Source: University of Zurich

    Psoriasis is a chronic inflammatory autoimmune disease that manifests as red, scaly skin patches


    The role of interleukin-12 in psoriasis

    The research team of Burkhard Becher, Professor of Immunology and Team Leader Sarah Mundt from the UZH Institute of Experimental Immunology, systematically studied the role of interleukin-12 in psoriasis


    Interleukin-12 maintains the normal function of skin cells

    Detailed studies on mouse and human tissues have shown that various types of cells in the skin are also equipped with interleukin-12 receptors


    Improve psoriasis treatment

    "Our results show that blocking interleukin-12 is not advisable, so such drugs should no longer be used to treat patients with psoriasis," said Pascale Zwicky, the first author of the study and a doctoral student


    The findings of UZH researchers may be important for the treatment of other diseases


    Article title

    IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation



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