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"In the past, it was thought that pain started with nerve fibers in the skin, but recently we found another new organ that detects mechanical forces, such as punctures of pressure or sharp objects, and reactsStudy leader Professor Patrik Ernfors of Medical Biochemistry and Biophysics at the Karolinska Institute in Sweden saidin the latest study, researchers found a specific type of skin glial cell on the skin that forms a mesh network at the skin's subsurface boundary to convey harmful thermal and mechanical sensitivitiesThe findings were published in the journal ScienceDOI: 10.1126/science.aax6452we know that glial cells are not neurons, but they play multiple roles in the nervous systemThe protective layer of glial cells that surrounds the sensory nerves is usually thought to end in the outer layer of the skin, but Ernfors and his collaborators found that they extend almost to the surface and respond there to external pressure, Patrik Ernfors knew about the existence of the "new organ" for a long time and conducted a five-year studyHappily, the existence of the "new organ" is finally coming to lifeErnfors would like to know what this new pain organ looks like, how it works with the pain nerve tissue in the skin, and how activation of the organ leads to electrical impulses in the nervous system, leading to reflexes and pain experiences45 years ago, glial cells were found to extend into the dermis, but new findings suggest they can enter the epidermis further, forming a pressure detection networkPhoto: ScienceFor this reason, Ernfors uses optogenetic stimulation to trigger the reactions of these cells in the pads of the mouse foot, while keeping other sensors unaffectedThe mice reacted as if they were in a slight state of pain - retracting their feet and licking the irritating spots (just as our hands were scalded back and blowing small hands)By blocking the transmission of signals from new organs, the skin's sensitivity to mechanical irritation is reduced, but has no effect on the cold responseThis also explains the mechanism by which new organs are involved in needles and stress painnot ably, researchers have not confirmed whether the organ is also present in the human body, but given that all other sensory organs in mice are similar to humans, it is likely that "new organs" may also be present in the bodyProfessor Patrik Ernfors,, said: "In summary, this finding changes our understanding of the cellular mechanisms of the body's feelings, and it is important for understanding chronic pain"
References:sNew Pain organ discovery in the skins?Science: New pain organs found in skin