Science: new research on the culprit of T cell failure in cancer

November 10, 2019 news / Biovalley BIOON / - -- although the immunocheckpoint blocking therapy has significantly changed the situation of cancer treatment and has clinical effect in cancer treatment, not all tumors respond to this immunotherapy Resistance to treatment, which occurs in a variety of cancers, largely hinders this strategy In a new study, in two different types of colorectal cancer, colorectal cancer with high microsatellite instability (MSI CRC) in response to PD-1 blockade at immune checkpoints and microsatellite stable in response to PD-1 central therapy, the researchers found, MSS CRC - T cell failure in colorectal cancer They found that tumor infiltrating T cells failed in both types of colorectal cancer The difference is that T-cell failure in MSS CRC is driven by vascular endothelial growth factor A (VEGF-A), but not in MSI CRC The related research results were published in the Journal of science immunology on November 8, 2019 The title of the paper is "VEGF-A drives tox dependent T cell emission in anti – PD-1 – resistant microsatellite stable chromatic cancers" Picture from science immunology, 2019, DOI: 10.1126/sciimmunologol.aay0555 The researchers report that VEGF-A induces the expression of transcription factor tox in T cells, thereby activating failure specific transcription programs in these cells By using in vitro, in vitro and in vivo mouse studies, they confirmed that blocking PD-1 and VEGF-A together can restore the anti-tumor function of T cells, making MSS CRC sensitive to PD-1 blocking therapy, so as to better control the tumor of MSS CRC Therefore, this study emphasizes the further exploration of immunocheckpoint blocking therapy for resistant tumors, and how to identify the way to make them sensitive to this immunotherapy (bio Com) reference: Chang gon Kim et al VEGF-A drives tox dependent T cell expansion in anti – PD-1 – resistant microsatellite stable chromatic cancer Science immunology, 2019, DOI: 10.1126/sciimmune.aay0555