Science: New research reveals that elevated striatal dopamine can cause hallucinations

News April 4, 2021//---Psychotic disorders such as schizophrenia have brought a huge burden to human beings, society and the economy.

In a new study, researchers from the Cold Spring Harbor Laboratory in the United States and the University of Washington School of Medicine have developed a cross-species method of calculating mental illness to directly link the behaviors of humans and rodents and use this This method is used to study the neural basis of hallucination-like perception in mice.

These authors set up similar auditory detection tasks for humans and mice.

In humans, hallucination-like perceptions—high-confidence false alarms—are related to the propensity to experience spontaneous hallucinations and can be quantified by self-report questionnaires.

In summary, these authors established hallucination-like perception in mice as a quantitative behavior to simulate the subjective experience of the main symptoms of mental illness.

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