Science Paper Interpretation! Reveals the developmental origins of eczema and psoriasis

As part of a global human cell map of every cell type in the human body, this new comprehensive map of developing and adult skin is a valuable resource for scientists around the world.
may also provide a template for regenerative medicine to help scientists grow skin more efficiently in the lab.
our skin is like a barrier that protects us from bacteria or viruses and is vital to our health.
skin diseases such as atopic eczema and psoriasis are chronic diseases in which the immune system becomes overactive, causing the skin to itch or deflection, which can be very painful and susceptible to infection.
these diseases have a great impact on people's lives, but the trigger factors are unknown, there is no cure, even if there is, can only help alleviate symptoms, not cure the cause.
skin is a complex tissue made up of many different types of cells.
to understand how the skin is formed and how it is associated with adult health and disease, the researchers studied cells from developing skin that were compared to biopsy samples from healthy adults and patients with eczema and psoriasis.
using advanced single-cell technology and machine learning, they analyzed more than half a million skin cells to see exactly which genes were turned on in each cell.
this allows them to find out what each cell does and how it talks to each other.
the researchers were surprised to find that diseased skin cells have many of the same cellular mechanisms as developing cells.
The skin cell map reveals specific molecular signals from healthy developing skin to recruit immune cells and form protective layers," said co-author of the paper, Professor Muzlifah Haniffa of the Wellcome Trust Sanger Institute.
we were surprised to see that skin cells from eczema patients and psoriatic patients send the same molecular signals, which can overactivate immune cells and cause disease.
it's never been seen before.
the re-emergence of developing cellular pathways is a huge leap forward in our understanding of inflammatory skin diseases and provides a new way to find treatments.
Co-author Dr Gary Reynolds, of newcastle University, said: "While our study focused on inflammatory skin diseases, other inflammatory diseases such as rheumatoid arthritis or inflammatory bowel disease could be triggered in the same way.
study shows the importance of research into development and could open up entirely new avenues for the study of inflammatory diseases.
" study sheds light on the development of healthy skin tissue and reveals cells present in adult skin.
is of great significance to regenerative medicine, especially for burn patients.
, co-author of the paper and a co-author of the paper, said: "The study of skin cells cultured in the laboratory has been going on for decades.
, however, it is not always clear how the properties of these cells change in the laboratory environment.
by revealing the detailed composition of cells isolated from developing skin and adult skin, this skin cell map could serve as a template for researchers trying to rebuild healthy skin in regenerative medicine.
our data is public, and we hope it will help with research to build skin tissue in the lab.
"As part of the International Human Cell Map Program, which aims to create the human body's 'Google Maps', this skin cell map study reveals that research and development can not only help understand how tissues are formed in the first world, but can also provide important clues to disease," said Co-author Dr. Sarah Teichmann of the Wellcome Trust Sanger Institute.
this skin cell map reveals a new way of thinking about inflammatory diseases and is an important reference that other scientists can use to study the causes of the disease and develop potential new therapies.
" Reference: 1. Gary Reynolds et al. Developmental cell programs are co-opted in inflammatory skin disease. Science, 2021, doi:10.1126/science.aba6500. 2.Developmental origins of eczema and psoriasis discovered