Science published a trick: use inflammation to treat inflammation!

September 9, 2019 / BIOON / - scientists from Canada's Kenan biomedical research center (krcbs) have found a new way to treat a variety of autoimmune diseases including arthritis in the laboratory model Two million Canadians suffer from autoimmune diseases, which cause the body's immune system to attack its own tissues, such as arthritis or lupus These diseases are the most common and debilitating chronic diseases The treatment of autoimmune diseases has always focused on reducing the effectiveness of the immune system through immunosuppression Photo source: in a new study recently published in the Journal of Science Translational Medicine, researchers of krcbs try to explore whether an inflammatory antibody Ter119 can treat inflammation caused by autoimmune diseases Antibodies are proteins produced by the immune system that help prevent invaders, such as viruses or bacteria, from harming the body Ter119 is a special inflammatory antibody, which aims to destroy red blood cells "Immunosuppression has long been the cornerstone of the treatment of autoimmune diseases," said Dr Alan Lazarus, CO director of the collaborative project on hematoimmunology transformation of krcbs and lead author of this study "Our research provides new clues for diseases that are difficult to treat "Because of the way that Ter119 interacts in the laboratory model, it is an existing laboratory case for the treatment of patients with ITP, which is a bleeding disease and the immune system destroys platelets Using laboratory models, the researchers found that in addition to the therapeutic effect on ITP models, Ter119 also had a positive effect on three models of arthritis and transfusion related acute lung injury Dr Lazarus, a senior scientist at the blood service innovation center in Canada, said: "for patients, this may mean that a new treatment is only half a step away from success - although more research is needed "Because all of the work in this study was done in a laboratory model, the researchers used Ter119 as a treatment result for multiple arthritis models to ensure that their results were consistent It is also important that the diseases examined in this work are relatively acute disease models, unlike most patients with chronic autoimmune diseases The next step, Dr Lazarus said, will be to learn more about why some antibodies help fight autoimmune diseases Reference materials: Andrew R crow et al Treating murine infectious diseases with an anti everywhere antibody, Science Translational Medicine (2019) Doi: 10.1126/scitranslmed.aau8217