Science: Reduce the resistance of intestinal bacteria to antibiotics

A study published in the journal Science showed that a forgotten antibiotic, tamoxicillin , resulted in a lower choice of resistant bacteria than standard treatments for febrile urinary tract infections.

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"For a long time, intravenous treatment with the antibiotic cefotaxime has been the standard procedure

The currently published study is the result of the Swedish Public Health Agency's research on how to best use existing antibiotics at the request of the Swedish government

They studied 152 patients with fever (also called pyelonephritis) caused by a urinary tract infection, and these patients required intravenous antibiotics

"We clearly see, to accept less influence for the intestinal flora amoxicillin treatment group suffered

The clinical efficacy of tamoxicillin is the same as the standard treatment of cefotaxime, and the adverse effects are equivalent

Hanberger said: "The result will be that we see fewer options for resistant gut bacteria in hospitals, which may help reduce hospital-related infections caused by these bacteria

Original search:

"The clinical and microbiological efficacy of temocillin versus cefotaxime in adults with febrile urinary tract infection, and its effects on the intestinal microbiota: a randomised multicentre clinical trial in Sweden", Charlotta Edlund, Anders Ternhag, Gunilla Skoog Ståhlgren, Petra Edquist, Åse Östhol Balkhed, Simon Athlin, Emeli Månsson, Maria Tempé, Jakob Bergström, Christian G Giske and Håkan Hanberger, (2021),Lancet Infect Dis , published online on 28 October 2021, doi: https://doi.