Science reveals that adipose tissue resident macrophages produce PDGFcc to control fat storage in the body

In order to adapt to the daily and seasonal changes in caloric intake, metazoans have evolved adipose tissue specifically for dynamic storage and release of energy

Macrophages are phagocytes that can eliminate unsuitable cells, microorganisms and metabolic waste, and produce a large number of biologically active molecules and growth factors

Based on this, in a new study, researchers from the United States and Germany hypothesized that resident macrophages associated with fat storage cells may also support their functions

Using a combination of genetic and pharmacological methods, these authors found that the lack of resident macrophages prevents wild-type mice and Ccr2-/- mice from being fed a high-fat diet and anorexia leptin receptor deficiency Lipid storage in fat cells in mice

A schematic diagram of the control of obesity by macrophages.

In summary, these data confirm the evolutionary conserved function of adipose tissue-resident macrophages, which links energy intake with fat storage in adipocytes through the production of PDGFcc, and is independent of CCR2-dependent macrophage promotion Inflammation

Reference materials:

Nehemiah Cox et al.

Conan JO O'Brien et al.