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Obesity has caused a huge and growing burden of disease globally
Obesity has caused a huge and growing burden of disease globally
2021 Nian 7 Yue 2 Hao , published in the S a study on the cience determine a rare non-synonymous mutation associated with a higher or lower BMI genes, providing insight into the genetics of human obesity .
Researchers sequenced the exomes of 645,626 individuals from the United Kingdom, the United States, and Mexico, and estimated the association between rare coding variants and body mass index (BMI), which is used to define obesity in clinical practice A measure of overall obesity
The researchers identified 16 genes, among which the burden of rare non-synonymous variants is related to BMI and has statistical significance in the exome range (inverse variance weighted meta-analysis P<3.
P CALCR MC4R GIPR GPR151 GPR75
A truncated variant of the protein in GPR75 was found in about 4/10,000 sequenced populations, and the risk of obesity in heterozygous carriers was reduced by 54%
A truncated variant of the protein in GPR75 was found in about 4/10,000 sequenced populations, and the risk of obesity in heterozygous carriers was reduced by 54%
Discovery of BMI-related genes based on exome sequencing
Protein truncation variants in C ALCR are associated with higher BMI and obesity risk, and LEP , POMC , PCSK1 ,and MC4R (but not LEPR ) are associated with higher BMI
C ALCR LEPs of POMC PCSK1 of MC4R LEPR UBR2 ANO4 PCSK1 of MC4R in
These results indicate that inhibition of GPR75 may be a treatment strategy for obesity and illustrate the ability of large-scale exome sequencing to identify large-effect coding variant associations and drug targets for complex traits
References References : : P ARSA Akbari , Ankit GilaniSequencing of 640,000 exomes Identifies GPR75 variants Protection from Associated with ObesityScience 02 Jul-2021: Vol.
373, Issue 6550, eabf8683.
The DOI: 10.
1126 / science.
abf8683
P ARSA Akbari , Ankit Gilani Science 02 Jul 2021: Vol 373, Issue 6550, eabf8683.
DOI: 10.
1126 / science.
abf8683 in this message