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    Home > Active Ingredient News > Immunology News > Science: scientists have successfully used the chain reaction of nine enzymes to make the HIV drug islatravir

    Science: scientists have successfully used the chain reaction of nine enzymes to make the HIV drug islatravir

    • Last Update: 2019-12-10
    • Source: Internet
    • Author: User
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    December 10, 2019 / Bio Valley bio on / - recently, in a research report published in the international journal Science, researchers from Merck and kedicos successfully used a nine enzyme chain reaction method to manufacture HIV drug - islatravir; in the article, researchers described their inspiration and the effect of the final product Photo source: Wikipedia researchers point out that a variety of natural products are the result of many basic elements of biosynthesis Many organic experiences use the selectivity of enzymes to complete each step, which usually involves a multi-step chain reaction, the first of which will be used as the basis for the next step Based on this, researchers began to look for ways to make the experimental HIV drug islatravir First, they focused on the bacterial nucleoside salvage pathway (NSP) In pathway), this process is mainly involved in the recovery of bases and nucleosides from RNA degradation to DNA In this process, there are three main enzymes, namely, deoxyribose-5-phosphate aldolase (Dera), pentoxyribose-5-phosphate aldolase (PPM), and purine nucleoside phosphorylase (PNP) In order to use the same process to develop the drug islatravir, researchers need to take advantage of a special property of enzymes, that is, inverse property, which can make them different from traditional catalysts Researchers must find a way to make the above three enzymes accept unnatural substrates The solution is to borrow reverse NSP from RNP and ppm of E In order to make it work, researchers must also modify the enzymes to make them more active This work also involves optimizing the other two enzymes and using the other four enzymes in the natural state The final result is the cascade reaction involving nine enzymes, and finally the drug islatravir can be produced The researchers say that compared with the multi-step synthesis, purification and protection technology involved in the previous development process, this new technology is obviously a huge progress Original source: Mark A Huffman, Anna fryszkowska, Oscar alvizo, et al Design of an in vitro biocatalytic cascade for the manufacture of islatravir, Science (2019) Doi: 10.1126/science.aay8484
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