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Blood vessels provide nutrition for tumors, on the other hand, they also spread cancer cells throughout the body
.
The sedimentation of circulating tumor cells in distant organs is promoted by factors induced by the primary tumor itself
Malignant tumors spread throughout the body by releasing cancer cells into the blood.
Cancer cells can reach distant organs and metastasize there
.
The success of tumor cell growth and metastasis in the blood circulation is highly dependent on the characteristics of the local environment
But so far, people know little about how the microenvironment of seed tumor cells (that is, the metastatic niche) evolves with the growth of metastatic cells
.
To answer this question, a research team from Heidelberg and Mannheim led by Helmut Augustin, together with colleagues from University College London, studied mice whose primary tumors were surgically removed
The researchers analyzed the overall gene expression of the metastatic niche in the lungs, paying particular attention to lung metastasis
.
They found that in the presence of primary tumors, endothelial cells inside blood vessels will produce LRG1 (leucine-rich 2-glycoprotein 1) in large quantities
How does the progression of metastasis change when the key molecule LRG1 is blocked by antibodies? In fact, scientists can slow the metastatic growth of breast and lung tumors in this way
.
One of the most surprising findings of this study is that LRG1 is not only produced by blood vessels at the metastasis site, but also produced by endothelial cells throughout the body and released into the circulation
Original title:
Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis.
DOI: https://
