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This article is original by Translational Medicine Network.
Please indicate the source for reprinting.
Author: Liz Zee Guide: Chinese scientist Hao Lin of Rutgers University applied traditional cupping therapy to the injection of new crown vaccine and invented a new transfer The method of infection is simple and painless, and there is no side effect of electrotransfection.
The combination of this method of transfection and DNA vaccine avoids the shortcomings of other new coronavirus vaccines that must be stored in cold storage! Researchers at Rutgers University studying COVID-19 used a suction technique similar to ancient cupping to invent a new method of delivering DNA molecules to skin cells
.
This research was published in the scientific journal Science Advances on November 5, and the article is titled "Novel suction-based in vivo cutaneous DNA transfection platform"
.
https:// In laboratory tests in mice, the research team used aspiration method to deliver the SARS-CoV-2 DNA vaccine, which gave the vaccine a strong immunity Response-about 100 times stronger than the vaccine alone
.
Based on the results of the study, the funder of the study, the biopharmaceutical company GeneOne Life Science (GeneOne Life Science, Inc.
) has approved the technology to enter human clinical trials of the COVID-19 vaccine
.
Based on the high safety and immunogenicity of this technology, human clinical trials have advanced to the second stage
.
The senior author of this study, Professor Hao Lin from the Department of Mechanical and Aerospace Engineering at Rutgers University New Brunswick, said: “This suction technique is a completely non-invasive way after the injection of nucleic acid.
Apply moderate negative pressure to the skin
.
This method is easy to use, cost-effective and highly accessible, and can be used for clinical applications and laboratory use for those researching nucleic acid therapy and vaccines
.
"Cupping is a traditional therapy that heats the cup.
Then put it on the skin to generate negative pressure and enhance blood circulation in the area
.
Nucleic acid therapy is a new generation technology that uses DNA, RNA and other biological molecules to control genetic information
.
Due to the bright prospects of nucleic acid in the treatment of various diseases and the development of vaccines, nucleic acid has been extensively developed in the past 20 years
.
Recently, in order to fight the new crown epidemic, scientists quickly designed several nucleic acid vaccines, produced them, and distributed them to the masses on a large scale
.
Nucleic acid vaccine is to directly introduce foreign genes (DNA or RNA) encoding a certain antigen protein into animal cells, and synthesize the antigen protein through the expression system of the host cell to induce the host to produce an immune response to the antigen protein to achieve prevention And the purpose of treating diseases
.
The key step in this process is transfection, or in other words, the purified nucleic acid passes through the cell membrane and enters the cytoplasm (RNA) and nucleus (DNA) of the host cell
.
If DNA and RNA molecules are injected into tissues, they will not automatically enter the host cell, and unless they are protected, most of them will degrade rapidly
.
For example, the mRNA COVID-19 vaccine uses lipid nanoparticles to encapsulate mRNA to protect and help them pass through the host cell membrane, thereby producing encoded proteins and triggering an immune response
.
Another way is to deliver DNA into cells through a high-intensity electric field, but this method usually produces adverse reactions, including inflammation, pain, and tissue damage
.
But in this new study, after the purified DNA was injected, the researchers sucked directly at the injection site, creating negative pressure on the skin
.
The suction force creates tension and relaxes each layer of the skin, triggering the skin cells to absorb DNA molecules
.
The new method is simple, painless, and has no known side effects, Professor Lin said
.
He said: "Nucleic acid biologics are widely used and applied in clinics.
Improvements in delivery technology have played an important role.
Global vaccine distribution is an example
.
We have demonstrated another safe and effective transgene that can produce high levels of transgene expression.
Transfection method
.
The advantages of this transfection method include high cost-effective equipment, large-scale manufacturing, and low user training requirements
.
Due to the inherent advantages of DNA, it especially does not need to be refrigerated like other vaccines (DNA vaccines do not need to be refrigerated) This technology facilitates vaccination in remote areas with limited resources
.
Reference: https:// Note: This article aims to introduce medical research progress and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital for treatment
.
Recommendation·Activity Practitioners of Action Knowledge-Finding Causes Single-Cell Research and Creation Camp Hot·Article Gene Sequencing [BMJ] Benefits all mankind! The pain of rare disease diagnosis will become history, and whole-genome sequencing is an inevitable trend in medical development! Genetic disease treatment 【Science】The era of RNA drugs has arrived, and the future is boundless! It may soon bring new insights into cancer treatment [AACR sub-Journal] for patients with rarer genetic diseases! Gastric Cancer Atlas brings new treatment strategies! Scientific research [Science] Transplanting skin and nerves from genetically modified pigs can help humans, but the new era of xenotransplantation has not yet arrived.
New crown virus [The Lancet] The world's largest study of 12 million people: New crown vaccine booster against Delta How much protection can the aspect bring to you? Cancer Treatment [Science Sub-Journal] How to treat non-small cell lung cancer more effectively? Scientists at MIT have discovered a way to bring hope to patients! Novel Coronavirus [Nature Hot Discussion] Will the 28 million children in the United States benefit from the FDA's move? What is the role and significance of children's vaccinations against the new crown?
Please indicate the source for reprinting.
Author: Liz Zee Guide: Chinese scientist Hao Lin of Rutgers University applied traditional cupping therapy to the injection of new crown vaccine and invented a new transfer The method of infection is simple and painless, and there is no side effect of electrotransfection.
The combination of this method of transfection and DNA vaccine avoids the shortcomings of other new coronavirus vaccines that must be stored in cold storage! Researchers at Rutgers University studying COVID-19 used a suction technique similar to ancient cupping to invent a new method of delivering DNA molecules to skin cells
.
This research was published in the scientific journal Science Advances on November 5, and the article is titled "Novel suction-based in vivo cutaneous DNA transfection platform"
.
https:// In laboratory tests in mice, the research team used aspiration method to deliver the SARS-CoV-2 DNA vaccine, which gave the vaccine a strong immunity Response-about 100 times stronger than the vaccine alone
.
Based on the results of the study, the funder of the study, the biopharmaceutical company GeneOne Life Science (GeneOne Life Science, Inc.
) has approved the technology to enter human clinical trials of the COVID-19 vaccine
.
Based on the high safety and immunogenicity of this technology, human clinical trials have advanced to the second stage
.
The senior author of this study, Professor Hao Lin from the Department of Mechanical and Aerospace Engineering at Rutgers University New Brunswick, said: “This suction technique is a completely non-invasive way after the injection of nucleic acid.
Apply moderate negative pressure to the skin
.
This method is easy to use, cost-effective and highly accessible, and can be used for clinical applications and laboratory use for those researching nucleic acid therapy and vaccines
.
"Cupping is a traditional therapy that heats the cup.
Then put it on the skin to generate negative pressure and enhance blood circulation in the area
.
Nucleic acid therapy is a new generation technology that uses DNA, RNA and other biological molecules to control genetic information
.
Due to the bright prospects of nucleic acid in the treatment of various diseases and the development of vaccines, nucleic acid has been extensively developed in the past 20 years
.
Recently, in order to fight the new crown epidemic, scientists quickly designed several nucleic acid vaccines, produced them, and distributed them to the masses on a large scale
.
Nucleic acid vaccine is to directly introduce foreign genes (DNA or RNA) encoding a certain antigen protein into animal cells, and synthesize the antigen protein through the expression system of the host cell to induce the host to produce an immune response to the antigen protein to achieve prevention And the purpose of treating diseases
.
The key step in this process is transfection, or in other words, the purified nucleic acid passes through the cell membrane and enters the cytoplasm (RNA) and nucleus (DNA) of the host cell
.
If DNA and RNA molecules are injected into tissues, they will not automatically enter the host cell, and unless they are protected, most of them will degrade rapidly
.
For example, the mRNA COVID-19 vaccine uses lipid nanoparticles to encapsulate mRNA to protect and help them pass through the host cell membrane, thereby producing encoded proteins and triggering an immune response
.
Another way is to deliver DNA into cells through a high-intensity electric field, but this method usually produces adverse reactions, including inflammation, pain, and tissue damage
.
But in this new study, after the purified DNA was injected, the researchers sucked directly at the injection site, creating negative pressure on the skin
.
The suction force creates tension and relaxes each layer of the skin, triggering the skin cells to absorb DNA molecules
.
The new method is simple, painless, and has no known side effects, Professor Lin said
.
He said: "Nucleic acid biologics are widely used and applied in clinics.
Improvements in delivery technology have played an important role.
Global vaccine distribution is an example
.
We have demonstrated another safe and effective transgene that can produce high levels of transgene expression.
Transfection method
.
The advantages of this transfection method include high cost-effective equipment, large-scale manufacturing, and low user training requirements
.
Due to the inherent advantages of DNA, it especially does not need to be refrigerated like other vaccines (DNA vaccines do not need to be refrigerated) This technology facilitates vaccination in remote areas with limited resources
.
Reference: https:// Note: This article aims to introduce medical research progress and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital for treatment
.
Recommendation·Activity Practitioners of Action Knowledge-Finding Causes Single-Cell Research and Creation Camp Hot·Article Gene Sequencing [BMJ] Benefits all mankind! The pain of rare disease diagnosis will become history, and whole-genome sequencing is an inevitable trend in medical development! Genetic disease treatment 【Science】The era of RNA drugs has arrived, and the future is boundless! It may soon bring new insights into cancer treatment [AACR sub-Journal] for patients with rarer genetic diseases! Gastric Cancer Atlas brings new treatment strategies! Scientific research [Science] Transplanting skin and nerves from genetically modified pigs can help humans, but the new era of xenotransplantation has not yet arrived.
New crown virus [The Lancet] The world's largest study of 12 million people: New crown vaccine booster against Delta How much protection can the aspect bring to you? Cancer Treatment [Science Sub-Journal] How to treat non-small cell lung cancer more effectively? Scientists at MIT have discovered a way to bring hope to patients! Novel Coronavirus [Nature Hot Discussion] Will the 28 million children in the United States benefit from the FDA's move? What is the role and significance of children's vaccinations against the new crown?
