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Excessive intake of sucrose during adolescence can cause cell damage to non-neuronal cell populations, inhibit the uptake of glucose from the blood into the brain parenchyma, cause certain neuronal dysfunctions, and lead to the main symptoms of mental illness
.
In modern society, the intake of monosaccharides (sucrose, isomerized sugar (corn syrup)) from beverages and diet has increased significantly
.
Among teenagers with frequent mental disorders, the intake of simple sugars is higher than that of any other generation
As susceptibility genes for mental illness, we chose Glyoxylase-1 and -in-schizophrenia ia-1
.
By combining heterozygous mice with the environmental factors of excessive sugar intake during adolescence, we have successfully established a system that exhibits decreased sensorimotor gating function, decreased working memory, hyperactivity, abnormal EEG gamma band components, etc.
A new mouse model of mental disorder-like symptoms
In addition, through the analysis of this model mouse, we aim to determine the new phenotype and the mechanism of mental disorders
.
We found "cerebral microvascular disease"
