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Researchers from the Babraham Institute in the UK and VIB-KU Leuven in Belgium today published a study on mice in the journal Science Immunology, providing two solutions that may overcome the key clinical limitations of immune cell therapy
The basis of cell therapy is to purify the patient's cells, cultivate them in cell culture to improve their properties, and then inject them into the patient's body
There are many types of T cells, each of which has a unique function in our immune system
The first key finding of this study shows that once regulatory T cells become inflammatory cells, they will resist returning to their previously useful state
By comparing stable and unstable cells, the researchers identified molecular markers that indicate which cells are at risk of transitioning from regulatory cells to inflammatory cells
In addition to this cell purification method, the researchers also found that exposing regulatory T cells to an unstable environment can remove unstable cells from the mixture
The lead author of the paper, Dr.
Although the method described in this study needs to be validated in humans before being used in cell therapy trials, establishing a sound process to improve the stability of mouse cell populations will help lay the foundation for improved human immune cell therapy
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