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    Home > Active Ingredient News > Immunology News > Science Sub-Journal: New study identifies auxiliary T-cells in the lungs that help fight the virus

    Science Sub-Journal: New study identifies auxiliary T-cells in the lungs that help fight the virus

    • Last Update: 2021-01-18
    • Source: Internet
    • Author: User
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    JANUARY 10, 2021 /--- In a new study, researchers from the University of Basel in Switzerland have found immune cells that reside in the lungs that last long after an influenza attack.
    in mice showed that these auxiliary immune cells improved the immune response to re-infection of different influenza strains.
    findings could lead to the development of longer-lasting vaccines for rapidly mutated viruses.
    study was published in the January 8, 2021 issue of the journal Science Immunology under the title "T resident helper cells promote humoral responses in the lung."
    author of the paper is Professor Carolyn King of the Department of Biomedical Research at the University of Basel.
    images from CC0 Public Domain.
    at the beginning of the new coronavirus pandemic, questions began to be raised about how long immunity would last after being tested for SARS-CoV-2 infection.
    , the same problem is now with coVID-19 vaccination.
    plays a key role in immune memory -- the complex interactions of immune cells, antibodies and signaling substances that enable the body to fight known pathogens very effectively.
    researchers have now found a different set of immune cells in the lungs that are key to fighting the re-infection of the flu virus.
    may play a similar role in the re-infection of other pathogens that cause respiratory diseases.
    experiments in mice, the researchers described a group of memory T cells in lung tissue called resident auxiliary T cells, which persist long after an influenza attack.
    , co-lead author of the cell bank paper in lung tissue, explains, "There is relatively little understanding of memory T cells that reside in tissues.
    previous studies have focused on memory cells in blood and lymphatic tissue.
    " but it makes sense for the body to keep these cell libraries in infected tissues, where the same or similar pathogens may invade again.
    study, the researchers described two types of auxiliary T-cells in the lungs.
    type of auxiliary T cells releases signaling material when re-infected, equip other immune cells with more lethal "weapons" to fight re-infected pathogens.
    another type of auxiliary T-cell, previously thought to be mainly present in lymphatic tissue but not in lung tissue, has now been found to assist in the production of antibodies to immune cells (B cells) and are closely present in the lungs.
    they were able to demonstrate that these cells were directly close to the B cells that produce the antibodies, leading to a more effective immune response to different influenza viruses.
    these auxiliary T-cells may be an interesting starting point for developing a longer-lasting flu vaccine," said Co-author David Schreiner, co-author of the paper on long-term vaccine protection.
    ," he added, possibly providing vaccines with drugs that promote the formation of complementary T-cells that migrate to tissues.
    this end, further research and development is needed.
    (Bioon.com) Reference: 1. Nivedya Swarnalekha et al. T resident helper cells promote humoral responses in the lung. Science Immunology, 2021, doi:10.1126/sciimmunol.abb6808.2.Immune cells discovered in the lungs improve virus defense
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