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This article is converted Medicine original, reproduced please indicate the source Author: chen Introduction: In recent years, with the emergence and growth of light and heat therapy, it can deal with the issue became a target tumor scientists who have studied in what way.
Tumors are diseases caused by the abnormal proliferation of human cells.
According to the International Agency for Research on Cancer (IARC), there will be 28.
4 million new cancer cases worldwide in 2040, an increase of 47% from 19.
3 million in 2020.
In recent years, photothermal therapy has received more and more attention due to the advantages of precise and controllable treatment sites, high killing efficiency and low side effects.
Researchers have now developed a variety of carriers, hoping to accurately deliver therapeutic drugs to the tumor site.
However, due to tumor heterogeneity and individual differences, the enrichment effect needs to be improved.
Tumor tissue has dense extracellular matrix and high interstitial osmotic pressure, which further limits the penetration of the carrier into the tumor.
In addition, small residual lesions on the edge of the tumor site after treatment are also likely to cause tumor metastasis and recurrence.
Therefore, it is the dream of scientists and doctors all over the world to promote the enrichment and penetration of drugs in tumor sites.
Recently, a researcher published a study titled "Near-infrared light-triggered platelet arsenal for combined photothermal-immunotherapy against cancer" in Science Advances.
Studies have shown that: by loading platelets with photothermal nanoparticles and immune agonists, a new type of platelet biomimetic dosage form can be prepared.
The biomimetic formulation realizes an efficient tumor photothermal-immune combined therapy on an animal model, which is not only conducive to more removal of tumor cells, but also conducive to inhibiting tumor metastasis and recurrence.
How to accurately and efficiently deliver photothermal materials to the tumor site is the key to solving the current dilemma.
According to the researchers, platelets are called "vascular guards", which naturally adhere to damaged blood vessels and can form thrombi and secrete nanovesicles in an activated state.
Therefore, the researchers proposed a delivery strategy that uses platelets as a carrier.
They treat platelets as "bullet shells" and pack polymer nanoparticles with high light-to-heat conversion efficiency as "munitions.
"
With the help of the natural properties of platelets in the body, it selectively adheres to defective tumor blood vessels.
Under low-power near-infrared light irradiation, the local acute vascular damage of the tumor caused by photothermal can activate the adherent platelets, and form thrombi in the tumor blood vessels through the cascade effect, thereby forming photothermal nanoparticles and immune agonists.
Ammunition Depot".
The enriched platelets can further secrete nano-scale platelet vesicles in the above-mentioned activated state, transport the photothermal nanoparticles and immunoagonists to the depths of the tumor tissues, and expand the scope of "attack".
Schematic diagram of the role of platelet-based biomimetic formulations in tumor photothermal-immune combined therapy.
In the eyes of researchers, this is not only conducive to photothermal removal of more tumor cells, but also enhances the immunogenicity of tumor antigens.
In animal experiments Completely inhibit tumor metastasis and recurrence.
Simply put, the basic principle of this therapy is to deliver photothermal materials to the tumor site, convert the light energy of the near-infrared laser into heat energy, and ultimately achieve the goal of "heating" dead tumor cells.
The loaded nanoparticles, drugs, etc.
have good flexibility, and platelets can be obtained from patients or donors.
Therefore, the platelet biomimetic dosage form has a good clinical application prospect in the field of individualized and precise treatment of tumors.
According to the researchers, the above results have completed the construction of humanized platelet formulations, and confirmed significant efficacy in patient-derived tumor xenograft models that reconstruct the humanized immune system, but they are still in preclinical studies at the animal level.
The clinical efficacy remains to be further confirmed. References: https://advances.
sciencemag.
org/content/7/13/eabd7614 Recommended reading [New research] Scientists have discovered that the cells that cause transplant rejection are actually.
.
.
healthy or unhealthy.
.
.
how sperm" Remember" the life experience of the father and pass it on to the offspring? [New Development] The "darling" of medicine|Burning fat? Half an hour before exercise can accelerate fat burning Cell Res | New discovery, Shanghai Institute of Biochemical Cells Yang Hui team revealed the assembly mechanism of CRISPR-related transposase Click here to read the original text
Tumors are diseases caused by the abnormal proliferation of human cells.
According to the International Agency for Research on Cancer (IARC), there will be 28.
4 million new cancer cases worldwide in 2040, an increase of 47% from 19.
3 million in 2020.
In recent years, photothermal therapy has received more and more attention due to the advantages of precise and controllable treatment sites, high killing efficiency and low side effects.
Researchers have now developed a variety of carriers, hoping to accurately deliver therapeutic drugs to the tumor site.
However, due to tumor heterogeneity and individual differences, the enrichment effect needs to be improved.
Tumor tissue has dense extracellular matrix and high interstitial osmotic pressure, which further limits the penetration of the carrier into the tumor.
In addition, small residual lesions on the edge of the tumor site after treatment are also likely to cause tumor metastasis and recurrence.
Therefore, it is the dream of scientists and doctors all over the world to promote the enrichment and penetration of drugs in tumor sites.
Recently, a researcher published a study titled "Near-infrared light-triggered platelet arsenal for combined photothermal-immunotherapy against cancer" in Science Advances.
Studies have shown that: by loading platelets with photothermal nanoparticles and immune agonists, a new type of platelet biomimetic dosage form can be prepared.
The biomimetic formulation realizes an efficient tumor photothermal-immune combined therapy on an animal model, which is not only conducive to more removal of tumor cells, but also conducive to inhibiting tumor metastasis and recurrence.
How to accurately and efficiently deliver photothermal materials to the tumor site is the key to solving the current dilemma.
According to the researchers, platelets are called "vascular guards", which naturally adhere to damaged blood vessels and can form thrombi and secrete nanovesicles in an activated state.
Therefore, the researchers proposed a delivery strategy that uses platelets as a carrier.
They treat platelets as "bullet shells" and pack polymer nanoparticles with high light-to-heat conversion efficiency as "munitions.
"
With the help of the natural properties of platelets in the body, it selectively adheres to defective tumor blood vessels.
Under low-power near-infrared light irradiation, the local acute vascular damage of the tumor caused by photothermal can activate the adherent platelets, and form thrombi in the tumor blood vessels through the cascade effect, thereby forming photothermal nanoparticles and immune agonists.
Ammunition Depot".
The enriched platelets can further secrete nano-scale platelet vesicles in the above-mentioned activated state, transport the photothermal nanoparticles and immunoagonists to the depths of the tumor tissues, and expand the scope of "attack".
Schematic diagram of the role of platelet-based biomimetic formulations in tumor photothermal-immune combined therapy.
In the eyes of researchers, this is not only conducive to photothermal removal of more tumor cells, but also enhances the immunogenicity of tumor antigens.
In animal experiments Completely inhibit tumor metastasis and recurrence.
Simply put, the basic principle of this therapy is to deliver photothermal materials to the tumor site, convert the light energy of the near-infrared laser into heat energy, and ultimately achieve the goal of "heating" dead tumor cells.
The loaded nanoparticles, drugs, etc.
have good flexibility, and platelets can be obtained from patients or donors.
Therefore, the platelet biomimetic dosage form has a good clinical application prospect in the field of individualized and precise treatment of tumors.
According to the researchers, the above results have completed the construction of humanized platelet formulations, and confirmed significant efficacy in patient-derived tumor xenograft models that reconstruct the humanized immune system, but they are still in preclinical studies at the animal level.
The clinical efficacy remains to be further confirmed. References: https://advances.
sciencemag.
org/content/7/13/eabd7614 Recommended reading [New research] Scientists have discovered that the cells that cause transplant rejection are actually.
.
.
healthy or unhealthy.
.
.
how sperm" Remember" the life experience of the father and pass it on to the offspring? [New Development] The "darling" of medicine|Burning fat? Half an hour before exercise can accelerate fat burning Cell Res | New discovery, Shanghai Institute of Biochemical Cells Yang Hui team revealed the assembly mechanism of CRISPR-related transposase Click here to read the original text
