Science Sub-Journal Reveals: Secret Weapon to Suppress Tumor Recurrence - β Blocker Blocker

In a study published December 2 in Translation Scienceal Medicine, researchers at AstraZeneone and the Wistar Institute and others found that the reactivation of tumor cells relied on neutral granulocytes and stress hormones, and that β-blockers prevented tumor cells in mice from reactivation.
this presents promising treatment strategies for delaying or preventing tumor recurrence.
: Science Translational Medicine Epidemiology and clinical studies have shown that chronic stress is associated with cancer progress.
In mouse models of diffuse sleeping tumor cells, researchers found that stress hormones such as epinephrine, epinephrine, and cortisol were able to induce neutrophic granulocytes to rapidly and release the inflammatory S100A8/A9 protein in large quantities through beta-2-adrenaline.
S100A8/A9 induces myelin peroxidase (MPO) to be active, causing lipid oxide to accumulate in neutral granulocytes.
after the release of lipid oxide, the fibroblast growth factor (FGFR) path path in tumor cells is raised to relieve sleep and form new tumor lesions.
researchers tested two drugs.
, specific beta-2-epinephrine can be antagonist (β-blocker, β-blocker) ICI-118551 can stop neutral granulocytes from secreting S100A8/A9, and ICI-118551 has no cellular effect on neutrogenic granulocytes.
β-subject blockers inhibit the secretion of neutral granulocyte S100A8/A9 (Source: Science Translational Medicine) Another drug, S100A8/A9 blocker tasquinod, significantly reduces the frequency of tumor lesions in stress mice.
ThaquineMod inhibits tumor occurrence (Source: Translational Medicine) Researchers also collected serum samples from 80 lung cancer patients who had their tumor surgically removed, and found that high concentrations of S100A8/A9 in the serums of these lung cancer patients were associated with shorter recurrence times.
the relationship between S100A8/A9 and recurrence times in lung cancer patients (Source: Science Translational Medicine) Based on these findings, the researchers recommend that cancer patients be given β-blockers, which may be an effective way to prevent the recurrence of certain types of cancer.
addition, blocking the drugs produced by S100A8/A9 may be a better approach.
"We hope to develop targeted therapies to break this mechanism and greatly extend the time it takes for tumors to remission."
AstraZenecom's chief scientist on cancer immunology, said.
reference: 1 s Michela Perego et al. Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils. Science Translational Medicine (2020) 2 s Stress Can Activate Neutrophils, a Type of Immune Cells, to Reawaken Dormant Tumor Cells and Trigger Res Cancer (Source: The Wistar Institute) 3 s levels of highs of stress hormone may reawaken cancer cells (Source: Healthing.ca)