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    Home > Active Ingredient News > Endocrine System > Science Sub-Journal: Scientists find new ways to tackle eating disorders and obesity

    Science Sub-Journal: Scientists find new ways to tackle eating disorders and obesity

    • Last Update: 2021-05-08
    • Source: Internet
    • Author: User
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    Scientists have identified potential drug targets for the treatment of obesity and eating disorders (such as anorexia nervosa), and there is currently no treatment.

    It is known that the ablation of hypothalamic AgRP (Agouti-related protein) neurons can cause fatal anorexia, and their activation can stimulate greedy eating and inhibit other motivational states, including fear and anxiety.
    Although AgRP neurons play a key role in bidirectional control of eating, there is currently no specific treatment for this circuit.

    In a new study published in the journal Science Translational Medicine, a team of researchers from the University of Michigan and Vanderbilt University pointed to a protein called melanocortin 3 receptor (MC3R), It is the way to enter the brain circuit, which controls the body's energy balance and food intake.

    A protein called melanocortin 3 receptor (MC3R) is a way to enter the brain circuits that control the body's energy balance and food intake.
    A protein called melanocortin 3 receptor (MC3R) is a way to enter the brain circuits that control the body's energy balance and food intake.

    This study in mice provides preliminary evidence that manipulation of MC3R can stimulate or inhibit food intake.

    Prove that manipulation of MC3R can stimulate or inhibit food intake.
    Prove that manipulation of MC3R can stimulate or inhibit food intake.

    MC3R is located on the surface of neurons, where it sends and receives signals about the overall energy balance in the body.
    Although this protein is found throughout the brain, it is especially common in the brain regions that control eating in mice and humans.

    The results of the study showed that MC3R is expressed in multiple brain regions, and showed sexual bimodal expression in some regions of mice and humans.
    The lack of MC3R produces various forms of anorexia bimorphism, similar to all aspects of human anorexia nervosa.
    However, in AgRP neurons, there is no gender difference in the expression of MC3R, and 97% of neurons express MC3R.
    The chemical genetic manipulation of arc-shaped MC3R neurons and the pharmacological manipulation of MC3R played an effective two-way regulation on the feeding behavior of male and female mice, respectively, and the full ablation of MC3R-expressing cells produced fatal anorexia.
    The pharmacological effects of MC3R compounds on food intake depend on the complete AgRP circuit in mice.

    Therefore, the dominant role of MC3R seems to be to regulate the AgRP circuit in male and female mice, in which the sexual dimorphic site plays a specialized and subordinate role in feeding behavior.

    In other words, MC3R is a potential treatment target for diseases characterized by anorexia, as well as a potential target for weight loss treatment.

    MC3R is a potential treatment target for diseases characterized by anorexia, as well as a potential target for weight loss treatment.
    MC3R is a potential treatment target for diseases characterized by anorexia, as well as a potential target for weight loss treatment.

    Patrick Sweeney, a neuroscientist at the UM Institute of Life Sciences, said that the two main areas of the brain receive all peripheral information about weight and energy balance: the hypothalamus and the brainstem.
    Studies have found that MC3R is most expressed in the hypothalamus, and we believe that it plays a leading role in regulating the entire neuronal circuit that controls food intake.

    When energy storage is too high, MC3R receives hormonal signals from this location in the hypothalamus and activates neural circuits that inhibit food intake.
    Conversely, the receptor can also sense that the body needs more energy and activate pathways that stimulate food intake.

    When energy storage is too high, MC3R receives hormonal signals from this location in the hypothalamus and activates neural circuits that inhibit food intake.
    Conversely, the receptor can also sense that the body needs more energy and activate pathways that stimulate food intake.
    When energy storage is too high, MC3R receives hormonal signals from this location in the hypothalamus and activates neural circuits that inhibit food intake.
    Conversely, the receptor can also sense that the body needs more energy and activate pathways that stimulate food intake.

    ARH MC3R neuron activation increases eating and reduces anxiety

    ARH MC3R neuron activation increases eating and reduces anxiety

    MC3R agonism inhibits PVN MC4R neurons in vivo

    MC3R agonism inhibits PVN MC4R neurons in vivo

    For this study, the researchers examined the behavior and feeding response of mice lacking MC3R protein.
    They found that mice showed many of the same characteristics as humans with anorexia.
    In some cases, the behavioral responses of male and female mice are very different-similar to the difference in humans, in humans, approximately 90% of anorexia nervosa is
    diagnosed as female.

    diagnosis

    The research team also determined that operating MC3R can change feeding habits in two directions.
    When the researchers treated mice with compounds that stimulate protein activity, they showed increased eating habits and reduced anxiety.
    Compounds that inhibit MC3R produced the opposite effect-reducing food intake, but no increase in anxiety was observed.

    If these results are translated into humans, the team believes that MC3R has the potential to play a role in a series of diet and obesity treatments.

    Michelle Bedenbaugh, a neuroscientist at Vanderbilt University School of Medicine, the lead author of the study, said: "The most exciting part of these results is that MC3R may become a potential therapeutic target for appetite disorders (such as anorexia) and obesity.
    We can achieve the transition from mice to humans, so this will undoubtedly help humans.
    "

    Researchers emphasize that the identification of drug targets in model organisms is an essential early step in the long process of developing effective therapies.

    Roger Cone, the senior author of the study, director of LSI and professor of molecular and integrated physiology at UM School of Medicine, said: "This provides us with a new way to solve this circuit and clarifies the focus of drug development.
    Therefore, this is The first step in drug development, but it is clearly critical.
    "

    In fact, the MC3R circuit has never been visualized like it is now, and the involvement of neuroendocrine and behavioral circuits has greatly expanded its importance to energy homeostasis.

    The MC3R circuit has never been visualized as it is now, and the involvement of neuroendocrine and behavioral circuits has greatly expanded its importance to energy homeostasis.
    The MC3R circuit has never been visualized as it is now, and the involvement of neuroendocrine and behavioral circuits has greatly expanded its importance to energy homeostasis.

    Original source:

    Original source:

    The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia.
    DOI: 10.
    1126/scitranslmed.
    abd6434

    The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia.
    DOI: 10.
    1126 / scitranslmed.
    abd6434


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