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This discovery overturned people's long-standing views on the mechanism behind this disease, strengthened the importance of prevention, and provided a way to study the origin of other types of cancer
Cancer is caused by DNA mutations.
Melanoma is a serious skin cancer that starts in skin cells that produce pigment
Most cancers are thought to be mutations directly caused by DNA damage, which then replicate to subsequent cells during the normal process of cell replication
DNA is composed of four chemical bases that exist in pairs-adenine (A) and thymine (T), cytosine (C) and guanine (G)
These mutations may not cause the disease immediately—on the contrary, they may lie dormant for many years
"Safe sun protection measures are very important
A method called "Circle Damage Sequencing (CD-seq)" developed by Pfeifer's laboratory made these discoveries possible.
Seung-Gi Jin, Dean Pettinga, Jennifer Johnson, Peipei Li, Gerd P.