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This article is converted Medicine original, reproduced please indicate the source Author: Yun Introduction: Researchers Laval University and Laval University of Quebec, Canada Research Center found that platelets in the treatment of systemic lupus erythematosus can play a key role.
Systemic lupus erythematosus is an autoimmune disease that can cause chronic inflammation in various parts of the body, especially inflammation of the joints, skin, brain, and kidneys.
Its incidence is four out of 10,000, and the age of onset is usually 20 to 40 years old.
The incidence of women is 9 times that of men.
Systemic lupus erythematosus occurs in many ways, and it can be difficult to diagnose and treat.
Recently, researchers from the University of Laval and the Laval Research Center of the University of Quebec in Canada published a paper entitled "Platelets release mitochondrial antigens in systemic lupus erythematosus" in the journal Science Translational Medicine, pointing out that platelets can play a role in systemic lupus erythematosus.
Play a key role.
Circulating DNA in the blood of patients with systemic lupus erythematosus causes an inflammatory response in the human body.
Researchers from the University of Laval and the Laval Research Center of the University of Quebec in Canada found that part of this DNA comes from platelets, and platelets mainly play a role in blood clotting, which allows people to better understand the disease and treat it more effectively .
The common feature of the disease is the presence of anti-DNA antibodies in the blood.
"When DNA circulates freely in the blood, immune complexes form and accumulate in the tissues where systemic lupus erythematosus is located.
So far, we don't know the exact source of this genetic material.
" The research center researcher said .
In cooperation with professor and clinical researcher Paul R.
Fortin, Boilard's team analyzed the blood samples of 74 patients with systemic lupus erythematosus and found that platelets are the source of extracellular DNA.
"To be precise, DNA is present in platelet mitochondria.
Most of the DNA in the blood we studied is actually still present in mitochondria.
The
body produces antibodies against mitochondria and mitochondrial DNA because it thinks they are foreign bodies," said Professor Boilard .
After activating platelets, mitochondria and their DNA are released.
Boilard said: "But this activation does not seem to involve normal platelet function, such as preventing bleeding.
If we can figure out how to interrupt this activation process, we can prevent the release of mitochondria and mitochondrial DNA, which will reduce our systemic Autoimmune response to lupus erythematosus.
"Today's video content recommendation [Feature Film] "My 2020" Chief physician Yang Xinrong, Liver Cancer Institute, Fudan University: Patients are the best textbooks, care for patients with liver cancer, and benefit from the people!
Systemic lupus erythematosus is an autoimmune disease that can cause chronic inflammation in various parts of the body, especially inflammation of the joints, skin, brain, and kidneys.
Its incidence is four out of 10,000, and the age of onset is usually 20 to 40 years old.
The incidence of women is 9 times that of men.
Systemic lupus erythematosus occurs in many ways, and it can be difficult to diagnose and treat.
Recently, researchers from the University of Laval and the Laval Research Center of the University of Quebec in Canada published a paper entitled "Platelets release mitochondrial antigens in systemic lupus erythematosus" in the journal Science Translational Medicine, pointing out that platelets can play a role in systemic lupus erythematosus.
Play a key role.
Circulating DNA in the blood of patients with systemic lupus erythematosus causes an inflammatory response in the human body.
Researchers from the University of Laval and the Laval Research Center of the University of Quebec in Canada found that part of this DNA comes from platelets, and platelets mainly play a role in blood clotting, which allows people to better understand the disease and treat it more effectively .
The common feature of the disease is the presence of anti-DNA antibodies in the blood.
"When DNA circulates freely in the blood, immune complexes form and accumulate in the tissues where systemic lupus erythematosus is located.
So far, we don't know the exact source of this genetic material.
" The research center researcher said .
In cooperation with professor and clinical researcher Paul R.
Fortin, Boilard's team analyzed the blood samples of 74 patients with systemic lupus erythematosus and found that platelets are the source of extracellular DNA.
"To be precise, DNA is present in platelet mitochondria.
Most of the DNA in the blood we studied is actually still present in mitochondria.
The
body produces antibodies against mitochondria and mitochondrial DNA because it thinks they are foreign bodies," said Professor Boilard .
After activating platelets, mitochondria and their DNA are released.
Boilard said: "But this activation does not seem to involve normal platelet function, such as preventing bleeding.
If we can figure out how to interrupt this activation process, we can prevent the release of mitochondria and mitochondrial DNA, which will reduce our systemic Autoimmune response to lupus erythematosus.
"Today's video content recommendation [Feature Film] "My 2020" Chief physician Yang Xinrong, Liver Cancer Institute, Fudan University: Patients are the best textbooks, care for patients with liver cancer, and benefit from the people!
