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    Home > Active Ingredient News > Digestive System Information > 【Science Sub-Journal】Shocked! A team of foreign universities found that it is the culprit that affects the growth and movement of pancreatic cancer cells!

    【Science Sub-Journal】Shocked! A team of foreign universities found that it is the culprit that affects the growth and movement of pancreatic cancer cells!

    • Last Update: 2022-11-01
    • Source: Internet
    • Author: User
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    This article is the original of Translational Medicine Network, please indicate the source of reprinting

    Written by Sophia

    Pancreatic cancer, a particularly aggressive pancreatic cancer, is pancreatic ductal adenocarcinoma, which has an expected survival of less than six months and is known
    as the "king of cancer".
    Features of the disease that are difficult to treat include its ability to suppress the immune system and its complex location and structure, which complicates
    the implementation of surgery and chemotherapy.

    A team of Virginia Tech researchers studied
    a bacterium found in pancreatic cancer tumors.
    The research team found that this bacterium can metastasize into pancreatic cancer tumors, which may help guide future treatments
    for pancreatic cancer.
    The bacterium, called Fusobacterium nucleotensians, may play a key role
    in the aggressive growth of cancer and in the movement of the whole body.
    The findings were published Oct.
    18 in Science Signaling
    .

    style="box-sizing: border-box;" _msthash="251139" _msttexthash="381004">Research background

     01 

    With further research, the tumor microbiome is increasingly linked
    to cancer progression and resistance to chemotherapy.
    In pancreatic ductal adenocarcinoma (PDAC), a high intratumoral burden on Fusobacterium nucleata is associated
    with shorter survival.
    So a team at Virginia Tech investigated the underlying mechanisms of
    this association.

    Because this microorganism is a common oral bacteria, it is often used to study its relationship
    with oral diseases such as periodontitis and gingivitis.
    But little
    is known about how microbes enter and adapt to life in the tumor microenvironment, thereby increasing the aggressiveness of cancer growth.
    Cancer studies have confirmed the microbe's presence in pancreatic cancer, leading Verbridge and his team to wonder if the bacteria might also activate tumor migration
    in the pancreas.

    "The tumor microbiome can influence cancer progression, so our goal is to better understand the role of
    these bacteria in cancer," Udayasuryan said.
    It wasn't until early 2022 that the tumor microbiome was recognized as a marker
    of cancer.
    Cancer biology and infection biology are often thought of as separate fields of study, but the recent merger of the two has revealed fundamental insights
    into cancer progression.
    Our research focus is at the forefront of this emerging paradigm, which is to study something
    unprecedented.

    The study found

     02

    When first analyzing the migration of infected pancreatic cancer cells, the researchers encountered an unexpected obstacle: They found that the number of cells migrating was difficult to quantify because the total number seemed to greatly exceed the number
    of cells they expected to find in the system.

    Using in vitro tumor microarray models, Verbridge and his team confirmed that the microbe can bind to and invade pancreatic cancer cells, then secreting molecules
    that stimulate cancer cells to accelerate their growth.
    This finding explains why the team saw more
    cells in their experiments than they expected.
    And it also allowed them to identify the increased
    migration of infected cells.

    In another important finding, they found that the microbe can infect non-tumor normal pancreatic tissue cells
    .
    When normal cells are infected in their experiments, they continue to grow normally; However, its presence stimulates nearby cancer cells to grow and spread
    faster.

    This new insight expands current thinking
    about non-cancer cells in and around tumor cells and how cancer spreads so aggressively.
    Any cell infected by a microbe may be more likely to develop cancer cell growth or even metastasis at some later time, which is how
    most cancers end up killing their hosts.

    Research implications

     03 

    With an understanding of how bacteria in tumors affect cancer growth and spread, scientists can design more effective chemotherapy or immunotherapies
    .
    These results also help develop diagnostic and prognostic tools to help detect cancer
    early.

    "While we have demonstrated that F.
    nucleatum can drive pancreatic cancer cell proliferation and migration, it is not yet known to what extent these results can translate to living systems or human patients, and the next steps will be important work in the future, ultimately telling us whether this knowledge will lead to more effective therapies
    tailored to the patient's own microbial composition.
    " Host-microbiome interactions are complex because many bacterial populations actually support human health and have been shown to improve the efficacy
    of cancer treatment.

    Resources:

    https://medicalxpress.
    com/news/2022-10-bacteria-pancreatic-cancer-cells.
    html

    style="white-space: normal;box-sizing: border-box;" _msthash="251157" _msttexthash="19521346">Note: This article is intended to introduce the progress of medical research and cannot be used as a reference
    for treatment options.
    If you need health guidance, please go to a regular hospital
    .

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