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Tissue-resident memory T cells (T-RM cells) are a new type of tissue-resident, new long-acting memory T cells that express CD69 and CD103 enriched on the cell surface
Tissue-resident memory T cells (T-RM cells) are a new type of tissue-resident, new long-acting memory T cells that express CD69 and CD103 enriched on the cell surface
In addition to the existence of peripheral tissues, T-RM cells also exist in the brain and blood-brain barrier
On April 13, 2022, the journal Science Translational Medicine published two articles back-to-back, revealing that T-RM cells depend on CD4 + helper T cells to participate in the pathological process of central nervous system immune system diseases
The research team of Roland S.
The research team of Roland S.
They found significant T-cell infiltration in the brains of patients with autoimmune encephalitis, of which about 60% were CD8-positive T-RM cells located close to neurons
Depletion of CD8-positive T cells in the peripheral blood of Orex-HA mice following T cell stimulation did not reduce the loss of hypothalamic neurons
Lymphocytic choriomeningitis is an acute infectious disease caused by lymphocytic choriomeningitis virus (LCMV)
Lymphocytic choriomeningitis is an acute infectious disease caused by lymphocytic choriomeningitis virus (LCMV)
They found large numbers of T-RM cells in both the acute active phase in patients with multiple sclerosis and in patients with neuromyelitis optica spectrum disorder
Depletion of peripheral CD8-positive T cells did not affect the expansion of T-RM cells, nor did it alter the dyskinesias of the mice
In general, the above two articles use different immune effector animal models to induce the residency of T-RM cells in the brain, and the emergence of local neuroimmune responses mimics neuroimmune disease states, and found that CD4 + helper T cells are T-RM cells.
Original source:
1.
1.
2.
Vincenti et al.
Tissue-resident memory CD8 + T cells cooperate with CD4 + T cells to drive compartmentalized immunopathology in the CNS .
Sci.
Transl.
Med.
14, eabl6058 (2022).
Tissue-resident memory CD8 + T cells cooperate with CD4 + T cells to drive compartmentalized immunopathology in the CNS
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