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This article is original by Translational Medicine.
Please indicate the source for reprinting.
Author: Liz Zee Guide: Vitamin A is a fat-soluble nutrient that can be absorbed by intestinal epithelial cells and converted into retinol
.
Vitamin A metabolites are essential for intestinal adaptive immunity because it directs the development of B cells and T cells and promotes their entry into the intestine
.
Therefore, lack of vitamin A will increase the susceptibility of intestinal infections
.
Immunologists and geneticists at the University of Texas Southwestern Medical Center have discovered how vitamin A enters the immune cells of the intestine.
These findings can provide insights for the treatment of digestive diseases and may also help improve the effectiveness of certain vaccines.
Curative effect
.
The research paper was published today in "Science", and the paper is titled "Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity"
.
"Now that we have a better understanding of this important aspect of immune function, we may eventually be able to manipulate how vitamin A is delivered to the immune system for disease treatment or prevention," Howard Hughes Medical Institute (Howard Hughes Medical Said Lora Hooper, a researcher at the University of Texas Southwestern Medical Center and Professor of Immunology
.
Dr.
Hooper, a professor at the Center for Host Defense Genetics at the University of Texas Southwestern Medical Center, said that vitamin A is a fat-soluble nutrient that the human body converts into a molecule called retinol before using it, and then converts it into a molecule called retinol.
For retinoic acid, vitamin A is very important to every tissue of the human body
.
It is especially important for the adaptive immune system.
The adaptive immune system is part of the broader immune system.
It responds to specific pathogens based on immune memory, which is formed through exposure to diseases or vaccines
.
Dr.
Hooper said that although researchers know that some intestinal immune cells called bone marrow cells can convert retinol into retinoic acid, how they can obtain retinol to accomplish this task is still a mystery
.
Her laboratory studies how gut bacteria affect the physiological habits of humans and other mammalian hosts
.
The lead author, Dr.
Ye-Ji Bang, is a postdoctoral researcher in Hooper's laboratory.
He and his colleagues focused on serum amyloid A, a retinol-binding protein that is produced by some organs during infection
.
They used biochemical techniques to determine the cell surface proteins to which they were attached and identified low-density lipoprotein (LDL) receptor-related protein 1 (LRP1)
.
LRP1 was discovered more than 30 years ago by Joachim Herz, MD, a researcher at the University of Texas Southwestern Medical Center.
He is the director of the Neurodegenerative Transformation Research Center and a professor of molecular genetics, neurology and neuroscience
.
Herz laboratory mainly studies the molecular mechanisms by which members of the LDL receptor gene family act as signals and endocytosis receptors in the brain and blood vessel walls
.
The discovery of LDL receptors at the University of Texas Southwestern Medical Center in the United States earned Michael Brown and Joseph Goldstein, MD, the Nobel Prize in Physiology or Medicine in 1985
.
Dr.
Bang, Dr.
Hooper, Dr.
Herz, and his colleagues found that LRP1 is present on the intestinal myeloid cells and seems to be able to transport retinol to and from
.
Dr.
Hooper said that when researchers used genetic technology to delete this receptor gene in mice to prevent their bone marrow cells from taking vitamin A derivatives, the adaptive immune system in their intestines almost disappeared, T cells and B cells.
Cellular and the key component of adaptive immunity-molecular immunoglobulin A is significantly reduced
.
The researchers then compared the response of mice with LRP1 and mice without LRP1 to Salmonella infection
.
Those mice without LRP1 were quickly overcome by infection
.
The results of the study published in "Science" show that LRP1 is the carrier of retinol into bone marrow cells
.
Dr.
Hooper said that if researchers can develop a way to inhibit this process, they can inhibit the immune response to inflammatory diseases that affect the intestines, such as inflammatory bowel disease and Crohn’s disease
.
Alternatively, finding a way to enhance the activity of LRP1 can enhance immune activity and make oral vaccines more effective
.
Reference materials: https:// Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital
.
Popular·Article Gene Sequencing [Nature Sub-Journal] The largest DNAm gene research so far: the study of genetic variant tumors related to DNAm at 420,509 DNAm loci in the blood has been identified [Heavyweight] Scientists at Johns Hopkins University The discovery that the self-correction function of genes can resist blood cancer is expected to be a major breakthrough in the treatment of blood cancer! Genetic testing [Nature Sub-Journal] The 1.
5 million largest genome-wide association study has identified nearly 600 gene loci related to anti-social behavior, alcoholism, and opioid addiction.
The new coronavirus [Nature] is a heavyweight! Why can the delta mutant virus spread so quickly and fiercely? Scientists from the University of Cambridge will take you to understand its obesity and health [The Lancet] Be alert! After more than 9 million BMI measurements of more than 2 million people, it is found that young people aged 18 to 24 are at the highest risk of being overweight or obese in the next ten years.
New coronavirus [Nature] The world's first needle-free DNA vaccine is about to be used first in India! According to a survey of 28,000 people, its effectiveness is 67%, and it can even prevent Delta vaccine research [Cell] Have you been vaccinated against HPV? Scientists at Johns Hopkins University have discovered that if they are vaccinated while young, they will be protected from throat cancer and cervical cancer after 25 years.
Intestinal health [Research] "Universal" intestinal microbiota: 40,000 data confirm that antibiotics cause Recommendations for the direct causes of cancer·Activities The 3rd Shanghai International Cancer Conference The 5th Symposium on Modern Clinical Molecular Diagnosis
Please indicate the source for reprinting.
Author: Liz Zee Guide: Vitamin A is a fat-soluble nutrient that can be absorbed by intestinal epithelial cells and converted into retinol
.
Vitamin A metabolites are essential for intestinal adaptive immunity because it directs the development of B cells and T cells and promotes their entry into the intestine
.
Therefore, lack of vitamin A will increase the susceptibility of intestinal infections
.
Immunologists and geneticists at the University of Texas Southwestern Medical Center have discovered how vitamin A enters the immune cells of the intestine.
These findings can provide insights for the treatment of digestive diseases and may also help improve the effectiveness of certain vaccines.
Curative effect
.
The research paper was published today in "Science", and the paper is titled "Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity"
.
"Now that we have a better understanding of this important aspect of immune function, we may eventually be able to manipulate how vitamin A is delivered to the immune system for disease treatment or prevention," Howard Hughes Medical Institute (Howard Hughes Medical Said Lora Hooper, a researcher at the University of Texas Southwestern Medical Center and Professor of Immunology
.
Dr.
Hooper, a professor at the Center for Host Defense Genetics at the University of Texas Southwestern Medical Center, said that vitamin A is a fat-soluble nutrient that the human body converts into a molecule called retinol before using it, and then converts it into a molecule called retinol.
For retinoic acid, vitamin A is very important to every tissue of the human body
.
It is especially important for the adaptive immune system.
The adaptive immune system is part of the broader immune system.
It responds to specific pathogens based on immune memory, which is formed through exposure to diseases or vaccines
.
Dr.
Hooper said that although researchers know that some intestinal immune cells called bone marrow cells can convert retinol into retinoic acid, how they can obtain retinol to accomplish this task is still a mystery
.
Her laboratory studies how gut bacteria affect the physiological habits of humans and other mammalian hosts
.
The lead author, Dr.
Ye-Ji Bang, is a postdoctoral researcher in Hooper's laboratory.
He and his colleagues focused on serum amyloid A, a retinol-binding protein that is produced by some organs during infection
.
They used biochemical techniques to determine the cell surface proteins to which they were attached and identified low-density lipoprotein (LDL) receptor-related protein 1 (LRP1)
.
LRP1 was discovered more than 30 years ago by Joachim Herz, MD, a researcher at the University of Texas Southwestern Medical Center.
He is the director of the Neurodegenerative Transformation Research Center and a professor of molecular genetics, neurology and neuroscience
.
Herz laboratory mainly studies the molecular mechanisms by which members of the LDL receptor gene family act as signals and endocytosis receptors in the brain and blood vessel walls
.
The discovery of LDL receptors at the University of Texas Southwestern Medical Center in the United States earned Michael Brown and Joseph Goldstein, MD, the Nobel Prize in Physiology or Medicine in 1985
.
Dr.
Bang, Dr.
Hooper, Dr.
Herz, and his colleagues found that LRP1 is present on the intestinal myeloid cells and seems to be able to transport retinol to and from
.
Dr.
Hooper said that when researchers used genetic technology to delete this receptor gene in mice to prevent their bone marrow cells from taking vitamin A derivatives, the adaptive immune system in their intestines almost disappeared, T cells and B cells.
Cellular and the key component of adaptive immunity-molecular immunoglobulin A is significantly reduced
.
The researchers then compared the response of mice with LRP1 and mice without LRP1 to Salmonella infection
.
Those mice without LRP1 were quickly overcome by infection
.
The results of the study published in "Science" show that LRP1 is the carrier of retinol into bone marrow cells
.
Dr.
Hooper said that if researchers can develop a way to inhibit this process, they can inhibit the immune response to inflammatory diseases that affect the intestines, such as inflammatory bowel disease and Crohn’s disease
.
Alternatively, finding a way to enhance the activity of LRP1 can enhance immune activity and make oral vaccines more effective
.
Reference materials: https:// Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital
.
Popular·Article Gene Sequencing [Nature Sub-Journal] The largest DNAm gene research so far: the study of genetic variant tumors related to DNAm at 420,509 DNAm loci in the blood has been identified [Heavyweight] Scientists at Johns Hopkins University The discovery that the self-correction function of genes can resist blood cancer is expected to be a major breakthrough in the treatment of blood cancer! Genetic testing [Nature Sub-Journal] The 1.
5 million largest genome-wide association study has identified nearly 600 gene loci related to anti-social behavior, alcoholism, and opioid addiction.
The new coronavirus [Nature] is a heavyweight! Why can the delta mutant virus spread so quickly and fiercely? Scientists from the University of Cambridge will take you to understand its obesity and health [The Lancet] Be alert! After more than 9 million BMI measurements of more than 2 million people, it is found that young people aged 18 to 24 are at the highest risk of being overweight or obese in the next ten years.
New coronavirus [Nature] The world's first needle-free DNA vaccine is about to be used first in India! According to a survey of 28,000 people, its effectiveness is 67%, and it can even prevent Delta vaccine research [Cell] Have you been vaccinated against HPV? Scientists at Johns Hopkins University have discovered that if they are vaccinated while young, they will be protected from throat cancer and cervical cancer after 25 years.
Intestinal health [Research] "Universal" intestinal microbiota: 40,000 data confirm that antibiotics cause Recommendations for the direct causes of cancer·Activities The 3rd Shanghai International Cancer Conference The 5th Symposium on Modern Clinical Molecular Diagnosis
