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Focusing on scientific and technological innovation work, Peking University Third Hospital has built a broad stage for the entire hospital to carry out innovative work through platform construction, resource allocation, and funding support, creating a new ecosystem for scientific and technological development
Researcher Mao Fengbiao/Academician Qiao Jie's team established the first analysis platform for eccDNA data integration and epigenetic regulation prediction
On January 7, 2022, researcher Mao Fengbiao/Academician Qiao Jie's team from Peking University Third Hospital and Li Mingkun's team from Beijing Institute of Genomics, Chinese Academy of Sciences collaborated on the Nucleic Acids Research database ranked eighth in the field of Biochemistry & Molecular biology The paper " CircleBase: an integrated resource and analysis platform for human eccDNAs " was published in the special issue, and the database platform CircleBase was established to predict the function of extrachromosomal circular DNA (eccDNA) regulating gene expression at the epigenetic level.
With the rapid development of high-throughput sequencing technology, thousands of extrachromosomal circular DNA (eccDNA) have been found in the human genome
To address this issue, the research team built CircleBase, an integrated data resource and analysis platform for curating and annotating eccDNA in multiple cell types
The database platform includes six major sections: targeted genes, epigenetic regulation, regulatory elements, chromatin accessibility, chromatin interactions, and genetic variation
CircleBase database flow chart
This work was jointly completed by Peking University Third Hospital, Beijing Institute of Genomics, Chinese Academy of Sciences, Wuhan University People's Hospital and other institutions
Prof.
In January 2022, the team of Prof.
The important role of 3D printed porous titanium alloy implants in bone defect repair and reconstruction has been clinically verified, but due to the metal inertness of titanium alloys, its osseointegration performance still needs to be further improved
Omnidirectional light functional illuminator
After UV treatment, the hydrophilicity, cytocompatibility, and alkaline phosphatase activity of the porous Ti6Al4V scaffolds were significantly improved, while their original mechanical properties were still maintained
The main body of the research team is composed of the Department of Orthopedics of the Third Hospital of Peking University, Beijing Akcome Medical Device Company and the School of Engineering of Peking University.
With the deepening of research, while continuing to design and develop new products, the team gradually uses 3D printed titanium alloy microporous prosthesis to achieve osteogenic activation and therapeutic functionalization through technical means such as surface modification and drug loading.
Liu Zhongjun is the corresponding author of the paper, and Dr.
Professor Tian Yun's team prepared a new biological sealant that can realize suture-free dura mater repair in spinal surgery
In February 2022, the team of Professor Tian Yun from the Third Hospital of Peking University officially published a paper titled " High efficacy of tetra-PEG hydrogel sealants for suturelessdural closure " in Bioactive Materials , describing a new product based on tetraethylene glycol ( PEG), which has the advantages of simple operation, high safety, fast setting time, easy injection, good mechanical strength and strong tissue adhesion, etc.
Starting from the actual clinical needs, the research team innovatively prepared a new type of polyethylene glycol (PEG) hydrogel, which can form stable amide bonds with proteins on the surface of the dura mater through covalent bonds, which is effective during surgery.
In addition, the team also established a New Zealand white rabbit dural defect model, and confirmed that it can effectively prevent the occurrence of cerebrospinal fluid leakage and promote the repair and regeneration of the dura in vivo by means of MR, gross autopsy, histological staining and immunohistochemistry.
, to provide a feasible new treatment plan for dural repair in spinal surgery
.
In this study, a new type of PEG hydrogel was innovatively prepared, which is easy to operate during the operation.
It can be directly injected into the dural injury area by a double-barreled syringe to form a gel in situ, and it can be combined with the collagen and elastic fibers on the surface of the dura.
Proteins form strong covalent bonds to provide watertight repair effects quickly and stably
Tian Yun and Associate Researcher Wang Xing of the Institute of Chemistry, Chinese Academy of Sciences are the corresponding authors of the paper, and Dr.
Zhu Tengjiao of Peking University Third Hospital is the first author of the paper
.
The above research work has been supported by the National Key Research and Development Program-Key Project of Intergovernmental International Science and Technology Innovation Cooperation, the National Natural Science Foundation of China and the Youth Innovation Promotion Association of the Chinese Academy of Sciences
.