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    Home > Biochemistry News > Biotechnology News > Scientific interpretation: What is the difference between Aiweilan's Tongyan Needle and Rutianshi?

    Scientific interpretation: What is the difference between Aiweilan's Tongyan Needle and Rutianshi?

    • Last Update: 2022-01-11
    • Source: Internet
    • Author: User
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    This year, the Chinese medical cosmetology market has successively approved several regenerative medical cosmetology filler products, which caused a huge shock in the industry.
    Let’s review it together:

    April 13, 2021

    Huadong Medicine (000963) issued an announcement stating that the company's wholly-owned subsidiary Sinclair's medical beauty product Ellansé® has been awarded the "Medical Device Registration Certificate" by the State Food and Drug Administration
    .
    The product model approved this time is Ellansé-S, and the scope of application is for subcutaneous implantation to correct moderate to severe nasolabial folds

    .

    April 19, 2021

    The "Polylactic Acid Facial Filler" (trade name: Ai Weilan) of Changchun Shengbo Ma Biomaterials Co.
    , Ltd.
    was awarded the "Medical Device Registration Certificate" issued by the State Drug Administration

    .
    So far, the first domestic class III medical device of poly-L-lactic acid PLLA "Tongyan Needle" product has officially obtained access

    .

    June 25, 2021

    Amic's "Cross-linked sodium hyaluronate gel containing L-lactic acid-glycol copolymer microspheres" has been approved by NMPA for marketing, and the product will be named "Nu Tianshi"
    .

    Many medical and aesthetic colleagues are curious about the difference between the two newly approved products containing poly-L-lactic acid
    .
    So today, let’s talk about it first.
    What is the difference between Aiweilan Tongyanzhen and Rutianshishi?

    About ingredients

    We can see from the approval documents of the two products that the ingredients of Rutianshi are: cross-linked sodium hyaluronate gel containing L-lactic acid-glycol copolymer microspheres; Aiweilan's ingredients are: polylactic acid facial filler

    Therefore, to understand it literally, the compositional properties of the two are very different
    .
    One is hyaluronic acid with poly-L-lactic acid, and the other is pure poly-lactic acid

    .
    It is conceivable that the ratio of the two is completely different

    .
    So here, the author has to boldly put forward my own opinion: these should be two fillers of different properties, although they both have the function of facial filling, but in terms of speed of action, method of action, product performance and maintenance time, etc.
    All are different

    .

    And the medical beauty deeply sees "The First Year of Renewable Materials: How to Break Through the Daytime? "As stated in the article, the ingredient specifications of Rutiandi are as follows:

    Labeled content of L-lactic acid-ethylene glycol copolymer microspheres: 18%
    .

    In sodium hyaluronate gel: the labeled concentration of sodium hyaluronate is: 17 mg/mL; the labeled concentration of lidocaine hydrochloride is: 3 mg/mL
    .

    The product specification is: 0.
    75 mL

    .

    Then let’s look at Ai Wei Lan, the ingredients of each bottle of Ai Wei Lan are:

    150mg of poly-L-lactic acid;

    Sodium carboxymethyl cellulose 45mg;

    Mannitol 145mg
    .

    This means that Rutianshi is an injection of compound ingredients, which is a combination of hyaluronic acid and poly-L-lactic acid microspheres; while Ai Weilan is a pure baby-care injection, which is completely regenerated with poly-L-lactic acid ingredients.
    Type product

    .

    About ease of use

    We all know that traditional Tong Yan needles need to be reconstituted, and it may take three hours or more if the technology is not perfect
    .

    Rutianzhi is directly made into an injection and can be used directly; while Aiweilan can be reconstituted in 1 minute without agglomeration
    .

    Why can Ai Weilan reconstitute so quickly?

    1.
    Because the preparation process of Aiweilan is different

    .
    Aiweilan's MEC-SPACE series patented technology, the prepared microspheres with uniform size and smooth surface realize monodispersion after reconstitution, and the reconstitution takes less than 1 minute

    .
    The spherical shape has high biocompatibility, low tissue response and good dispersibility; rapid reconstitution, no agglomeration, and no foaming; smooth surface has high biocompatibility and low tissue response

    .

    2.
    Those who are familiar with Tongyan needle injection technology know that the concentration of injection is very particular

    .
    For example, PLLA particles of different particle sizes can actually perform different functions

    .
    5ml dilution can be injected deeply to support the growth of deep tissues; 10ml dilution can be injected in the middle layer, playing the unique "carving and luminous" effect of Tongyan needle (improving skin texture)

    .
    So, in the end, every experienced Tongyan needle injection doctor will form his own injection habits and preferences, and adjust different injection concentrations according to different injection sites

    .

    Picture: Ai Weilan's collagen regeneration effect is presented

    About the safety of injections

    In this regard, we must admit that no matter what kind of filler, there is a possibility of complications
    .
    As a doctor, we must be vigilant about the occurrence of complications

    .
    In this regard, our clinicians are rigorous

    .

    About PLLA particles

    The particle size of PLLA made during the day is a uniform 20-45um size, and Aiweilan's PLLA particles are also a uniform size of 20-50um.
    In this regard, it solves the problem that traditional baby beauty needle products tend to accumulate and agglomerate.
    Therefore, both technologies have improved in this regard

    .

    The difference is that the PLLA particles made by Daytime are distributed in the hyaluronic acid gel, while the PLLA particles made by Aiweilan directly contact the tissues to stimulate the growth of its own collagen
    .

    Picture: Ai Weilan's collagen regeneration effect is presented

    About the injection effect

    Because it has already been compounded during production, Rutianshizicai is equivalent to a mature product.
    After getting it, it can be injected directly like traditional hyaluronic acid

    .
    Therefore, the injection effect during the day depends mostly on the rheological characteristics of the gel, the technique and aesthetics of the injection doctor

    .
    Therefore, most of the injection effects are "what you see is what you get"

    .

    1.
    Aiweilan works by fully contacting tissue cells to produce more homogeneous collagen

    .
    Therefore, the collagen regeneration effect of Avilan depends more on the Avilan product itself

    .
    In other words, evaluating the effectiveness of Ai Wei Lan is actually based on "how much Ai Wei Lan can regenerate collagen".
    Although the doctor's technique is one aspect, the characteristics of the product itself are more important

    .

    2.
    I told you about Ai Wei Lan’s MEC-SPACE series of patented technology.
    This patent is powerful.
    It makes Ai Wei Lan’s PLLA particles evenly dispersed at the injection site, thus greatly reducing the possibility of nodules

    .
    You can see the picture below.
    At each time node, the arrangement of the new collagen in the Aiweilan group is very regular and even

    .

    3.
    Let's take a look at how Ivylan's collagen regeneration performance under PSR Sirius Red staining:

    4.
    The clinical effect of this one is a very natural and harmonious face

    .
    The injection doctor grasps the dose and level of injection, and it is easy to get started, and the effect of collagen regeneration is very natural and accurate:

    Picture: Ai Weilan's collagen regeneration effect is presented

    In summary, both products have their own advantages.
    With their advent, we have also entered the era of regenerative medical beauty.
    The author believes that the market and time are the standards for testing everything.
    Let us wait and see how it will develop in the future

    .

    About the safety of intravascular injections

    Whether injection products accidentally enter the blood vessel will cause embolism is a question that everyone has always been very concerned about
    .
    For products like hyaluronic acid, by establishing an animal model of intravascular injection in rats, it can be observed that after hyaluronic acid enters the blood vessel, it causes high damage to the vascular intima, severe inflammatory response, and blood vessel blockage

    .

    What kind of changes will be caused by the injection of Aiweilan into the blood vessel?

    After pathological observation and flap survival experiment, the results showed that: 24 hours after injection, there was no embolism in the lumen, and the integrity of the blood vessel wall was high; 7 days after injection, the flap survived well
    .

    And the pathological results and the flap survival test results were not significantly different from the results of the intravascular injection of the same amount of 0.
    9% sodium chloride solution in the control group

    .

    Pathological results pictures

    Therefore, it is preliminarily believed that the Aiweilan Tongyan needle is reconstituted according to the instructions and injected into the artery
    .
    No
    signs of vascular mechanical blockage or vascular embolism have been observed for the time being .
    In addition, Aiweilan Tongyan Needle is a liquid after compounding, which can be effectively withdrawn, and it also provides more protection for the safe operation of the doctor

    .

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