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    Home > Active Ingredient News > Antitumor Therapy > Scientific Reports: The role of prostate health index in predicting Gleason score upgrade of radical prostatectomy specimens and high-risk prostate cancer

    Scientific Reports: The role of prostate health index in predicting Gleason score upgrade of radical prostatectomy specimens and high-risk prostate cancer

    • Last Update: 2021-09-18
    • Source: Internet
    • Author: User
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    pixabay

    pixabay

    A major challenge in the treatment of prostate cancer (PCa) is the discovery of cancers that have not been managed by active surveillance (AS)


    A major challenge in the treatment of prostate cancer (PCa) is the discovery of cancers that have not been managed by Active Surveillance (AS)


    Of the 300 patients evaluated for PHI and undergoing prostate biopsy, 92 (30.


    Of the 300 patients evaluated for PHI and undergoing prostate biopsy, 92 (30.


    The RP specimens of 24 RP patients showed GS upgrade


    The RP specimens of 24 RP patients showed GS upgrade


    The predictors of poor pathological features of RP (bad pathological features: ≥pT3a or GS≥4+3) are shown in the figure below


    The predictors of poor pathological features of RP (bad pathological features: ≥pT3a or GS≥4+3) are shown in the figure below


    Although there have been a large number of reports on PHI, there are still relatively few studies on whether PHI can predict high-risk PCa


    Although there have been a large number of reports on PHI, there are still relatively few studies on whether PHI can predict high-risk PCa


    In summary , in ISUP GG 1+2, PHI can predict the GS upgrade when PIRADS≥4 lesions are combined
    .
    In ISUP GG 1+2, PHI can predict the GS upgrade when PIRADS≥4 lesions are combined
    .
    PHI alone can also assess the possibility of high-risk PCa with adverse pathological features after surgery
    .
    PHI may improve the detection of csPCa and provide prognostic information
    .
    This study provides an opportunity to determine the appropriate treatment strategy for AS candidate patients.
    It can also provide important help for pre-treatment consultation for all potential PCa patients, which will help the management of AS patients and patients considering RP
    .
    However , the predictability of PHI in several aspects of PCa needs further research
    .
    It provides an opportunity to determine the appropriate treatment strategy for AS candidates.
    It can also provide important help for pre-treatment consultations for all potential PCa patients, which will help the management of AS patients and patients considering RP
    .
    However , the predictability of PHI in several aspects of PCa needs further research
    .


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