echemi logo
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > 【Scientific Research Dynamics】Important progress in the research of Zhao Yanbing/Yang Xiangliang's research group: the radiofrequency field of bivalent gold nanoclusters activates tumor cell pyrozosis...

    【Scientific Research Dynamics】Important progress in the research of Zhao Yanbing/Yang Xiangliang's research group: the radiofrequency field of bivalent gold nanoclusters activates tumor cell pyrozosis...

    • Last Update: 2023-02-03
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit

    On December 29, ACS Nano, a journal of the American Chemical Society, published online the research paper "Radiofrequency-Activated Pyroptosis of Bi-Valent Gold" by Professor Zhao Yanbing and Professor Yang Xiangliang, School of Life Science and Technology, Huazhong University of Science and Technology, National Engineering Research Center for Nanomedicine Nanocluster for Cancer Immunotherapy”

    Cancer immunotherapy shows great potential
    in killing tumor cells.
    However, it is
    only effective
    in a small proportion of patients with features of "immunogenic thermal tumors" (≈10-30%).
    Cancer cell death patterns play an important role
    in regulating the tumor immune microenvironment.
    For example, as a programmed cell death mode related to adaptive immune response, pyroptosis provides great help
    for improving cancer immunotherapy by inducing immunogenic cell death (ICD), improving the infiltration of cytotoxic T lymphocytes, and triggering systemic immune response.
    Studies have shown that the Gasdermin
    E (GSDME) protein plays a key role
    in the pyroptosis process of tumor cells.
    Since the expression level of G
    SDME protein in most tumor cells is very low, this largely inhibits tumor cell pyroptosis, and only non-immunogenic apoptosis
    Although some DNA methyltransferase inhibitors (dicetabine, 5-azacytidine, etc.
    ) can effectively increase the content of GSDME in tumor cells, the lack of activation of G SDME
    protein still greatly limits the pyroptosis
    of tumor cells.
    It has been reported that it can effectively regulate caspase 3/GSDME-mediated pyroptosis of tumor cells by promoting the activation of caspase 3, thereby exerting inhibitory effects
    on tumors.
    However, how to achieve the specific transformation of tumor cells from apoptosis to pyroptosis through the Caspase 3 pathway and improve the effect of cancer immunotherapy is still a huge challenge

    Radiofrequency ablation (RFA) is one of the most commonly used methods of hyperthermia in the clinic, and Caspase 3-mediated apoptosis is the main pathway
    of tumor cell damage in the peripheral region of R FA (heat load < 50°C).
    Recently, non-invasive RFA procedures (radio frequency radiation) based on radiofrequency-responsive nanoparticles (RF-NPs) have attracted a lot of attention
    as a promising form of hyperthermia.
    Compared with traditional R
    FA, it does not need to insert electrode needles, has deep RF tissue penetration, flexible procedures, can accurately kill tumor cells, can activate caspase3 and continuously activate the immune response
    to a certain extent.
    In this work, the authors prepared radiofrequency-responsive bivalent gold nanoclusters (BI GC@PNA) using a two-step reduction method of weak reducing agent and strong reducing agent
    , which was modified by temperature-sensitive polymer to improve its in vivo behavior (cell uptake and intratumor retention,
    By adjusting the ratio of weak reducing agent and strong reducing agent to accurately adjust
    the Au(I)/Au(0) ratio in bi GC@PNA, the RF heating effect was precisely controlled, and its effect
    on cell pyroptosis was studied under a non-invasive RF field.
    Changes in GSDME and caspase 3 expression levels in tumor cells and tumor-bearing mice showed that
    biGC@PNA exhibited a definite radiofrequency heat-activated pyroptosis of tumor cells, as well as a strong radiofrequency-induced ICD effect and systemic immune response
    The combination with αPD-1 showed that radiofrequency response
    biGC@PNA showed excellent αPD-1 immunotherapy enhancement in inhibiting tumor lung metastasis, distant tumors, and re-attacking tumor growth
    BIGC@PNA as a nanoeffector that activates pyroptosis in tumor cells by radiofrequency is expected to be a new strategy to enhance cancer immunotherapy (Figure 1).

    ACS Nano is the world's leading journal
    in the field of nanoscience and materials.
    Qingqing Zhang, a doctoral student at the School of Life Science and Technology, Huazhong University of Science and Technology, is the first author
    of the paper.
    The research was supported by the National Basic Research Program of
    China (2020YFA0710700, 2018YFA0208900) and the National Natural Science Foundation of China (82172758, 81773653
    ) funding

    Article link: https://pubs.


    Figure 1 Radiofrequency-activated pyrosis of tumor cells in BI GC@PNA is used in cancer immunotherapy


    This article is an English version of an article which is originally in the Chinese language on and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to with relevant evidence.