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Scientists create the first human model of Reye's syndrome |
In the brain organoids of patients with Reye's syndrome, neurons cannot mature normally.
In the brain organoids of patients with Reye's syndrome, neurons cannot mature normally.
The team and collaborators of Professor Alessandro Prigione at the University Hospital of Düsseldorf in Germany used cell reprogramming technology to convert skin cells into stem cells that produce neurons.
Through these models, the researchers found that the patient's neuronal defects may be caused by insufficient nerve precursor energy.
This study provides a model for the neuropathological study of Reye's syndrome caused by SURF1 mutation for the first time, and provides a practical strategy for the treatment of this rare disease.
Related paper information: doi.
doi.