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Recently, Associate Professor Huang Haofei and Distinguished Professor Wang Ming of Shandong University of Technology reported a new strategy and method for preparing optically pure amino acids by liquid-liquid two-phase chiral extraction resolution.
Related results were published online in "Nature-Communication".
Liquid-liquid two-phase chiral extraction is a method for the resolution of racemic chiral compounds that has been rapidly developed in the past ten years, and has shown a very good industrial prospect in the production of optically pure amino acids.
However, traditional extraction methods can only perform chiral resolution from racemic amino acids, resulting in a maximum yield of only 50%, and the residual enantiomeric amino acids in the aqueous phase are not easy to recycle.
In response to this problem, the research team has done a lot of research work on new chiral extractants and extraction methods in recent years.
The research creatively developed a new chiral extractant molecule containing tert-butyl ketone structure, which achieved more than 99% enantioselectivity of chiral amino acids.
Subsequently, the team developed a new method of amino acid racemization under mild conditions, and coupled it with the extraction process, so that the extraction process of the amino acid racemization in the aqueous phase and the chiral amino acid in the organic phase can be performed synergistically.
In the end, the scientific research team ingeniously designed a continuous extraction-hydrolysis process and equipment, and successfully realized the continuous preparation of high-purity D-amino acids using L-type amino acids as the substrate and the extraction method, and completely solved the traditional extraction process yield.
Less than 50%, long extraction process and complicated process.
Compared with the enzyme-catalyzed dynamic kinetic resolution method and asymmetric synthesis, the preparation process has greater advantages in continuous production, substrate practicability, recyclable system, mild reaction conditions, and the like.
(Source: Wang Fang, China Science News)
Related results were published online in "Nature-Communication".
Liquid-liquid two-phase chiral extraction is a method for the resolution of racemic chiral compounds that has been rapidly developed in the past ten years, and has shown a very good industrial prospect in the production of optically pure amino acids.
However, traditional extraction methods can only perform chiral resolution from racemic amino acids, resulting in a maximum yield of only 50%, and the residual enantiomeric amino acids in the aqueous phase are not easy to recycle.
In response to this problem, the research team has done a lot of research work on new chiral extractants and extraction methods in recent years.
The research creatively developed a new chiral extractant molecule containing tert-butyl ketone structure, which achieved more than 99% enantioselectivity of chiral amino acids.
Subsequently, the team developed a new method of amino acid racemization under mild conditions, and coupled it with the extraction process, so that the extraction process of the amino acid racemization in the aqueous phase and the chiral amino acid in the organic phase can be performed synergistically.
In the end, the scientific research team ingeniously designed a continuous extraction-hydrolysis process and equipment, and successfully realized the continuous preparation of high-purity D-amino acids using L-type amino acids as the substrate and the extraction method, and completely solved the traditional extraction process yield.
Less than 50%, long extraction process and complicated process.
Compared with the enzyme-catalyzed dynamic kinetic resolution method and asymmetric synthesis, the preparation process has greater advantages in continuous production, substrate practicability, recyclable system, mild reaction conditions, and the like.
(Source: Wang Fang, China Science News)