Scientists discover double-sided genes that are both cancer-and-cancer and cancer-causing

scientists have found a gene that helps mice protect themselves fromof intestinaltumors, but the gene may also increase the risk of breast cancer spreadingThe discovery of the gene could be of great help in developing drugs to boost human cancer capabilities in the future, according to a study published in the latest issue of the British journal NatureThe team, led by Roger Reeves of Johns Hopkins University in the United States, found that the Ets2gene carried by mice withdisease
s similar to human Down syndromeinhibittheted the production oftumorThe findings address a long-running debate about whether the geneticdiseasehave a role in preventing cancerous tumorsDown syndrome is at a rate of about one in 800 newborns and affects physical and mental developmentThe patient carried a2 1 chromosome, so the total number of chromosomes is 47, one more than normal The researchers crossed the mice carrying extra 2
1 and another group of genetically modified , developed bowel cancer It was found that , had
a much lower risk of developing progeny than normal laboratory mice, a much smaller tumor even if they had cancer After further hybridization experiments
, Reeves narrowed the range of anti-tumor genes to 33 He then genetically engineered an experimental mice that carried only 33 genes and crossed them with cancer-prone mice, increasing the chances of a tumor in the offspring of the hybrid This suggests that genes that have anti-cancer effects work better in a number of cases This explains why people with Down syndrome are less likely to develop cancer because they carry more of a chromosome that contains an anti-cancer gene, Reeves said The next step is to continue to narrow the range of anti-tumor genes Finally, the researchers found the gene that was most closely linked to reducing the incidence of cancer, the Ets The results come as a surprise to researchers, as previous studies have shown that increased protein activity Ets 2 is linked to the spread of breast cancer As a result, David Sladgill, a geneticist at the University of South Carolina, says this contradiction must be resolved before more anti-cancer drugs with An Ets2-like effect can be developed and used in the future