Scientists explain why brain injuries turn smarter
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Last Update: 2021-03-16
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Source: Internet
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Author: User
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Zebrafish, Chinese Academy of Sciences Center for Brain Science and Intelligent Technology Excellence and Innovation
Many people feel smart after brain damage, is there a scientific basis for this? The study by the He Jie Research Group of the Center for Brain Science and Intelligent Technology Innovation of the Chinese Academy of Sciences answers two key questions about how glial cells respond to brain damage: How do damage-activated glial cells enter the cell cycle? How do damage-activated glial cells choose to produce glial cells or neurons? The study was published online by eLife.
the central nervous system of zebrafish has a strong ability of nerve regeneration after injury, so it has been used in recent years as an important animal model to study the mechanism of nervous regeneration of the central nervous system. Using random model analysis, single-cell sequencing, and in sit-in cell lineal tracking, the researchers found that radioactive glial cells in adult zebrafish were in a resting state, and that physical damage to the top cover led to abnormal proliferation of glial cells and glial proliferation under the damaged area.
further, it was found that physical damage could only induce some glial cells to enter the cell cycle, and that two consecutive physical damages at the same brain region activated two groups of partially overlapping glial cells. Random activation models are a good way to explain overlap rates. These analyses show that the glial cells of the active state are converted into a proliferative state with a fixed probability of entering the cell cycle.
, the researchers also found that glial cells had different cell states during the damage: resting, activating, and proliferating. The damage caused all resting radioactive glial cells below the damage point to change to an active state, but only 25% of the active cells changed to a proliferating state.
glial cells that damage the visual top cover mainly produce glial cells, producing only a very small number of newborn neurons (3% to 5%), which can survive for at least 300 days. More interestingly, the team found that suppressing the Notch signaling path path (from about 5 percent to about 20 percent) increased neuron production significantly during a specific window of time after the injury (4 to 5 days after the injury).
study found that a large number of new neurons are likely to come mainly from activated glial cells caused by injury. In other words, activated and non-proliferating cells induced by injury, once induced into the proliferative state, produce a large number of neurons. "And the over-generated neurons survive for less than 25 days, and the mechanisms behind them deserve further exploration." The researchers said. (Source: Huang Xin Hejing, China Science Journal)
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