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    Home > Biochemistry News > Biotechnology News > Scientists explore the creation of artificial organelles

    Scientists explore the creation of artificial organelles

    • Last Update: 2021-09-19
    • Source: Internet
    • Author: User
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    Figure: (a) Fe3+ ion triggers membrane fusion of exosomes customized by catechol (CEx)


    Source: Institute of Basic Science

    The human body is made up of many different types of cells.


    This is achieved through the reprogramming of "exosomes", which are vesicles (~120 nm in diameter) used by cells for signal transmission between cells


    They did this by modifying the surface of exosomes with a molecule called catechol


    The researchers first tested the effectiveness of the system by loading calcein-co2 + in one exosome and EDTA in the other


    Then, these customized exosomes are pre-loaded with different reactants and enzymes, turning them into biomimetic nanofactories


    Next, the researchers want to know to what extent these microreactors can be absorbed and internalized by cells


    Armed with this knowledge, the research team tried to create functional artificial mitochondria that can produce energy in cells


    CHO Yoon-Kyoung, the corresponding author of the study, pointed out: "In short, our results highlight the potential of these exosomes as nanoreactors in regulating the metabolic activities of cells in the sphere and reducing cell damage caused by hypoxia


    DOI

    10.


    Programmed exosome fusion for energy generation in living cells

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