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    Home > Food News > Food Articles > Scientists have cracked the effects of amyloid on muscle regeneration

    Scientists have cracked the effects of amyloid on muscle regeneration

    • Last Update: 2021-03-14
    • Source: Internet
    • Author: User
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    protein TDP-43 accumulates and functions during normal muscle growth and regeneration, according to a paper published online in Nature. TDP-43 is often associated with neuromuscular diseases such as amyotrophic lateral sclerosis (ALS) and is considered pathogenic. Researchers believe that muscle regeneration in disease can lead to harmful build-up of this protein.
    TDP-43 protein aggregation in skeletal muscles in patients with neuromuscular diseases such as amyopathy. Lowering TDP-43 levels can lead to age-related muscle weakness in mice and fruit flies, suggesting that TDP-43 may play a functional role in muscle formation.
    , Brad Olwin and colleagues at the University of Colorado at Boulder studied the function of TDP-43 during normal mammalian skeletal muscle formation. They found that it was abundant in muscle cells in mice and increased during the formation of skeletal muscle cells. Hereditary consumption of TDP-43 prevents cell growth and leads to cell death, indicating that the protein plays an important functional role in muscle regeneration. In addition, the researchers reported that during muscle cell growth in mice, the TDP-43 protein gathers to form a more complex structure, "muscle-particles," that can be transformed over time into amyloid protein structures, but is usually removed in functioning mature cells. Biopsy results from patients with muscle weakness confirmed the continued presence of muscle-particles in regenerative muscles.
    researchers believe that continuous muscle regeneration in neuromuscular disease may increase TDP-43 levels, but failure to remove the resulting muscle-particles may lead to the accumulation of pathogenic amyloid protein in the diseased muscles. Age-related factors may increase the risk of this transition. (Source: Jin Nan, China Science Daily)
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