Scientists have cultivated artificial skin to grow hair that promises to cure baldness

2004, when U.S. scientists first used stem cells from mouse skin to grow hair follicles, Jay Leno, the host of the well-known American talk show "The Tonight Show," joked that scientists had "cured baldness... At least in mice." Sixty-six years later, a new study in the academic journal Nature is finally taking an important step toward "curing" human baldness.
June 3, local time, Harvard Medical School and other institutions in the academic journal Nature introduced a new breakthrough in the field of artificial skin - the use of human ernally stem cells to grow hairy skin-like organs.
Journal specially invited Dr. Leo L. Wang, a dermatologist at the University of Pennsylvania School of Medicine, and Professor George Cotsarelis, director of dermatology, to write news and opinion papers on the results.
the results take people one step closer to "producing an unlimited number of hair follicles" that can be "transplanted to the scalps of thin or hairless people," the two said. "Furthermore, if this approach is applied clinically, those with wounds, scars and hereditary skin diseases will have access to revolutionary treatments."
George Cotsarelis told news.com.e. that he believes the paper is an important step in solving hair loss problems and hair transplants.
authors have shown that organs (artificial skin) can be transplanted into immunodeficiency mice and grow hair (human hair). This suggests that they can eventually be transplanted into the human scalp. "Immune deficiency mice were used to ensure that the grafts were not rejected by the mice's immune system.scientists began their research on skin tissue engineering in 1975. At the time, a landmark study found that formation cells can be separated from the surface of the skin and cultured in-body. About 10 years later, cells isolated from burn patients began to be used for skin grafts to save lives.
To take skin tissue engineering a step further, transplanted skin must contain more components of normal skin, such as hair follicles, melanin cells, sweat glands, nerves, muscles, fat, immune cells, and epidertic cells.
the study, which focuses on institutions such as Harvard Medical School in the United States.
Karl Koehler, an assistant professor of otolaryngology at Harvard Medical School, jiyon Lee, a research assistant, and colleagues report that organ culture systems can use human pluripotent stem cells to produce skin-like organs after carefully optimizing growth conditions.
skin organs cultured from human erythroid stem cells formed multiple layers of skin tissue, including hair follicles, sebum glands and neural circuits, after 4-5 months of culture. After transplanting it into the back skin of immunodeficient mice, 55% of the grafts had 2-5 mm of hair. This suggests that these organs can blend with the skin of mice to form skin with human hair.
the authors found that their organs had the characteristics of chin, cheeks and ear skin in gene expression. Other indications are that these organs may actually simulate scalp skin, and that by changing the culture conditions for cell growth, skin with different body parts can be customized.is a complex multi-layered organ involved in various processes such as body temperature regulation, fluid maintenance, tactile and pain perception. Rebuilding the skin and its associated structures has long been one of the major challenges in the biomedical community.
, in-body tissue generation can be challenging because cells do not grow in a normal environment, says Cotsarelis, a group of patients. "Hair and skin form in the right three-dimensional environment by coordinating the process of signaling molecules. It is challenging to do this manually, but the authors were able to simulate many of these processes in their organs. The
paper details the culture process of skin organs. Karl Koehler and colleagues added growth factors to stem cells, using inhibitors of bone morphological protein 4 (BMP4) and transformation growth factor-β (TGF-β) to induce skin formation. Next, they inhibited the cells with growth factor FGF2 and bone morphology protein (BMP) to induce the formation of cranial nerve cells, resulting in the production of the orthopaedic.
cells are placed in the sphere to grow. After more than 70 days, hair follicles begin to appear, eventually producing hair. Most of these hairs are dyed from melanin cells, which also develop from cranial nerve cells. The sebum glands, nerves and their subjects, muscles and adipose tissue associated with hair follicles then begin to build up, eventually forming a very complete skin.Studies by Karl Koehler et al. have demonstrated the potential of artificial skin in wound healing, preventing scarring, and hair transplants. But Leo L. Wang believes there are several issues that need to be addressed in this study before it can really be applied clinically.
, for example, how efficient and repetitive is hair? If used for transplantation, how many cells would it take to eventually form a hair follicle?
Cotsarelis told news.cotsarelis that the artificial skin lacks immune cells, and there is no evidence that the hairs it grows can cycle like human hair.
also noted that in laboratory studies, artificial skin needs to be prepared for 140 days before implanting in mice, which may hinder its therapeutic potential. In reality, skin grafts for burn patients can't wait that long.
despite these claims, Lee and colleagues' research is an important step toward 'curing' human baldness and paves the way for other, greater treatment possibilities," he said. "This work has great clinical potential, and we believe that hope will eventually become a reality."