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Guide: Researchers have reported a new type of tanite nanoparticle preparation that blocks the formation of plaque and tooth decay in a day.
if hair loss is an adult's problem, tooth decay is a common headache for people of all ages.
statistics, the incidence of dental caries in China's youth is more than 50%, the incidence of dental caries in middle-aged people is more than 80%, and the proportion of the elderly is more than 95%.
If not treated in a timely manner, this common bacterial disease of hard tissue in the teeth will cause myelitis and periodontitis, and may even cause inflammation of the groove and jaw, seriously affecting the health and life of patients.
now, the disease may have met the "Crest".
At the Recent American Chemical Society (ACS) Fall 2020 Virtual Conference and Exhibition, researchers at the University of Illinois at Chicago reported on a new type of nirconium nanoparticle preparation that blocks plaque and tooth decay in a day.
researchers have applied for patents and the preparation may be widely used in dental clinics in the future.
human mouth contains more than 700 kinds of bacteria, including beneficial bacteria that help digest food or control other microorganisms, as well as harmful species, including streptococcus deformation.
these harmful bacteria can adhere to teeth and gather to form "biofilms", consuming sugar and producing acidic by-products that corrode tooth enamel, paving the way for "tooth decay".
Clinically, tin fluoride, silver nitrate, or silver fluoride are often used to suppress plaques and prevent further decay of teeth, and studies are trying to treat tooth decay with nanoparticles made of zinc oxide, copper oxide, etc., but the problem is that there are more than 20 teeth in the human mouth, and there is a risk of bacterial erosion, the reuse of these drugs will kill beneficial cells, and even cause harmful bacteria resistance.
, the researchers hope to find a way to protect the mouth from beneficial bacteria as well as tooth decay.
they turned their attention to the zircoxide nanoparticles.
particle is one of the important antibacterial materials, which has the advantage of low normal cytotoxicity and antibacterial system based on reversible price state transformation.
2019, researchers at Nan kai University systematically explored the possible antibacterial molybdenum oxide nanoparticles in Science China Materials.
doi: 10.1007/s40843-019-9471-7 According to a report by the researchers at the Conference, they produced zircina oxide nanoparticles by dissolving nitrate or ammonium sulfate in water, and studied the effect of the particles on the "biofilm" created by deformed streptococcus.
results show that although zircina oxide nanoparticles do not remove existing "biofilms", they reduce their growth by 40%, while under similar conditions, the clinically known anti-moth agent silver nitrate does not delay the development of "biofilms". "The advantage of this treatment is that it appears to be less harmful to oral bacteria, nanoparticles only prevent microbes from sticking to the substance and forming biofilms, and the particles are less toxic and metabolic to human oral cells in petri dishes than silver nitrate in standard treatments," said Russell Pesavento of the University of Illinois at Chicago, lead researcher on the
project.
, the team is trying to stabilize nanoparticles with coatings on neutral or weak alkaline pHs close to saliva.
future, researchers will test the treatment's effect on human cells in the lower digestive tract in a more complete oral microbiome, providing patients with a better overall sense of security.
resources: snr. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .