Scientists have discovered new ways to burn fat

, a metabolite, can affect a mouse's body temperature, energy consumption and weight through previously undiscovered thermothermia, according to a paper published online today.
energy intake is greater than consumption often leads to obesity. Generally speaking, there are two main ways to lose weight: one is to reduce food intake, reduce the need for metabolic calories; Heat is also the "fuel" needed for beige and brown fat. In contrast to white fat, which is good at storing energy and accumulates easily in obese bodies, beige and brown fat cells contain large amounts of mitochondrials, which also generate heat during the formation of energy molecules. For mammals, beige and brown fat play a very important role in regulating body temperature and protecting against cold, and mitochondrial heat production can burn calories, but studies have shown that activating beige and brown fat on demand is difficult.
Edward Chouchani of the Dana-Farber Cancer Institute in Massachusetts, USA, and colleagues screened metabolites that were high in brown fat and increased in low temperatures, and eventually the intermediate product of the process of releasing stored energy, succinate. When muscle activity such as shaking, serum acid is released into the blood and then absorbed by beige and brown fat cells. The researchers found that amber acid increased the local temperature of beige and brown fat in mice, and that mice that ate high-fat feed were able to avoid obesity by drinking water mixed with amber acid.
Joshua Rabinowitz of Princeton University in New Jersey and others note in a related article that it would make sense to further verify that serum acid also promotes fat burning in the body, and emphasizes that the difference between mice and humans is that there is relatively little brown and beige fat in the body and decreases with age. The researchers caution that this difference may limit the degree to which calories are consumed by activating the brown fat metabolic process. (Source: Lu Yi, China Science Daily)