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Although heart transplantation is used as the standard treatment for heart failure, transplant rejection remains a challenge
RNA (CircRNA) RNA FSCN1 (CircFSCN1) (Tol-DC) This study shows that knocking out CircFSCN1 gene can induce Tol-DCs .
Image source: http://creativecommons.
1967 20 70 ( ) ( ) ( )
Dendritic cells (DC) are considered to be the most powerful and versatile antigen-presenting cells (APC) , which regulate T cell immunity and immune tolerance, and play a key role in the allogeneic immune rejection of organ transplants
(DC) (APC) T organ transplant DC
Some in vitro studies have shown that small interfering RNA (SiRNA) treatments targeting immune genes or immunosuppressive agents ( such as rapamycin, transforming growth factor beta (TGF-b) and dexamethasone 11) can induce immunosuppressive effects.
Some in vitro studies have shown that small interfering RNA (SiRNA) treatments targeting immune genes or immunosuppressive agents ( such as rapamycin, transforming growth factor beta (TGF-b) and dexamethasone 11) can induce immunosuppressive effects.
Recent studies have shown that circular RNA (CircRNA) , which is endogenously expressed and produced by backward splicing , can regulate gene expression and molecular functions
RNA(CircRNA) Yu B CircRNA DC DC(MDCs) DC(ImDC) CircRNA CircRNA DC RNAFSCN1(CircFSCN1) DC MDCS (»2 ) CircRNA CircFSCN1 Fascin 1(FSCN1) DC CircFSCN1 (DCs) CircFSCN1 Tol-DCs
circFSCN1/ EF-1A dc circFSCN1
Image source: http://creativecommons.
http://creativecommons.
http://creativecommons.
In summary, the authors first reported and imDC compared exon CircFSCN1 in MDCS high expression
imDC CircFSCN1 MDCS CircFSCN1 Tol-DC CircFSCN1 TOL-DC CircFSCN1 CircRNA Bioon.
Reference
Bowen Wang, MD et al.
Preventing alloimmunerejection using circular RNA FSCN1-silenced dendritic cells in heart transplantation.
J Heart Lung Transplant.
2021 Apr 8; S1053-2498(21)02266-X.
doi:10.
1016/j.
healun.
2021.
03.
025.
Preventing alloimmunerejection using circular RNA FSCN1-silenced dendritic cells in heart transplantation.
J Heart Lung Transplant.
2021 Apr 8; S1053-2498(21)02266-X.
doi:10.
1016/j.
healun.
2021.
03.
025.
Bowen Wang, MD et al.
Preventing alloimmunerejection using circular RNA FSCN1-silenced dendritic cells in heart transplantation.
J Heart Lung Transplant.
2021 Apr 8; S1053-2498(21)02266-X.
doi:10.
1016/j.
healun.
2021.
03.
025.