Scientists have found an effective way to restore impaired cognitive function in Alzheimer's disease

A team of neuroscientistes from the United States and Brazil have discovered a potential solution to cognitive loss caused by Alzheimer's disease by targeting protein synthesis in mice.
their findings, published in the journal Science Signaling, reveal that synthetic drugs can save brain cell activity and form memories.
Currently, treatment for Alzheimer's disease focuses on reducing disease-related symptoms such as amyloid plaques, nerve fiber tangles and neuroinstatic inflammation, and this study shows that adding a drug to restore protein synthesis can help restore normal brain activity.
the synthesis of new proteins in the brain is essential for the normal functioning of neurons, especially for memory consolidation.
we and others have previously shown that brain protein synthesis disorders can lead to memory defects in alzheimer's model mice, and that the brains of Alzheimer's patients show obvious signs of protein synthesis disorders.
, we wondered if restoring brain protein synthesis might be a way to improve memory function in Alzheimer's patients.
," added Eric Klann, a professor at New York University's Center for Neuroscience.
" our latest study shows that improving abnormal protein synthesis in the brain can restore lost cognitive function.
hope that this work will take a step forward in the treatment of this difficult disease.
study focused on a synthetic molecule, ISRIB, that promotes protein synthesis.
ISRIB was developed by Peter Walter of the University of California, San Francisco, specifically for the initial process of translation, which eventually stimulates cell protein synthesis.
, they tested whether ISRIB could save the memory of mice with Alzheimer's-like condition through a series of memory tests.
showed that ISRIB could indeed restore memory function in these mice and protein synthesis in the hema.
in mice with fully developed Alzheimer's-like diseases (simulating the advanced stages of the disease), their results suggest that ISRIB can also restore the plasticity and memory function of synapses in the hema region.
, the researchers' findings suggest that restoring protein synthesis, such as joining ISRIB, with the help of synthetic molecules can restore cognitive processes impaired by Alzheimer's disease.
source: Scientists findable avenue to restore cognitive function impaired by Alzheimer's disease Origin: Mauricio M. Oliveira et al., Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer's disease. Science Signaling, 02 Feb 2021: Vol. 14, Issue 668, eabc5429 DOI: 10.1126/scisignal.abc5429 This article was originally sourced from Bio Valley, for more information please download Bio Valley APP (