Scientists have found out why embryo growth is restricted

and repeated miscarriage are common pregnancy-related diseases, which are closely related to micro-environmental abnormalities of the maternal immune system.
why would anyone miscarry repeatedly? Professor Wei Haiming and Professor Tian Zhigang of the Institute of Immunology of China University of Science and Technology collaborated to find that there are a large number of NK cell subgroups in the early pregnancy membrane tissue in humans and mice, which promote the development of embryos by secreting growth factors. The absence of this NK cell, which secretes growth factors, can result in restricted embryo growth. The results were recently published in the Journal of Cell Publishing Group
Journal.
the embryo development process needs to form a special mother-to-child interface to care for the normal development of the fetus. The mother-to-child interface consists of a large number of metastatic natural killer cells (dNK), which account for 70% of the total number of lymphocytes in the first three months of pregnancy, and it is not clear what role such a large number of dNK cells play in embryonic development.
group compared the functional gene differences between NK cells and extrinsic blood NK cells through whole gene screening, and found that the high expression of PTN and OGN in NK cells in early pregnancy was very important growth factors for early embryo development. HLA-G, expressed by fluffy outer nourishing layer cells from embryo sources, interacts with NK cells in the metastasse membrane, induces NK cells to express growth factors in large numbers and promotes embryonic development. In patients with repeated miscarriages, the ability of metastome NK cells to express growth factors was significantly reduced and could not support the normal development of early embryos.
In order to save the embryo growth caused by the decrease of NK cell secretion growth factor, the team induced membrane-like NK cells with bone marrow hematopoietic stem cells in in-body, and carried out intravenous follow-up infusion therapy in mice, and the pregnancy outcome of elderly mice and growth factor defective mice after transfusion improved significantly, and the embryo growth was restricted and alleviated.
The study found that NK cells have unique physiological functions to promote embryonic development in the part of metamorphosis tissue, and explored the directional induction of specific functional NK cell trans-transmission scheme, which provides new ideas for clinical treatment of related diseases such as restricted embryo growth and repeated abortion. (Source: Science and Technology Daily Wu Changfeng)