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    Home > Medical News > Medical World News > Scientists have found that different fats give different signals to the body

    Scientists have found that different fats give different signals to the body

    • Last Update: 2019-10-29
    • Source: Internet
    • Author: User
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    The body fat is not very popular now Those who hoard fat in the abdomen, buttocks, thighs, let the beauty lovers want to get rid of it Doctors also frequently warn that too much fat has a series of health risks, and even increases the risk of death In fact, there are different types of adipose tissue in our body, which cannot be generalized Most of them are white fat They store energy for food shortage, so they are often called "bad fat" ▲ fat cells can store oil (photo source: 123rf) The other kind of brown fat is different They are located near the nervous system, the collarbone and the kidney Brown adipose tissue produces heat and helps burn energy Other studies have suggested that people with more brown fat have a relatively lower risk of obesity or diabetes and are among the popular "good fats." Scientists have done a lot of research on the relationship between white fat and health and disease in the past, which is one reason why we are more and more aware of "bad fat" By contrast, we didn't know much about brown fat in the past Why might they have health benefits? Why do two kinds of fat have different effects on the body? The research presented today can help answer this question The study was recently published in cell metabolism Scientists at the University of Copenhagen in Denmark started with two proteins secreted by fat to see the difference between the signals sent by white and brown adipose tissue to other parts of the body "This is the first time that brown adipose tissue has been studied in such detail We mapped all the proteins that fat cells secrete and use to communicate with other cells, and we found a huge difference " "It's like two kinds of fat speak two different languages," said Camilla Sch é ele, Professor of the center for basic metabolism research at the Novo Nordisk foundation, who co authored the study ▲ the adipocytes studied and analyzed were from brown fat in the clavicle and white fat under the skin (picture source: reference [1]) The researchers used high-sensitivity mass spectrometry to analyze the proteomics of two kinds of fat cells The results showed that 471 secreted proteins were regulated differently in the two adipocytes From the classification of these proteins, we can see that brown fat has higher anti-inflammatory ability and is better at regulating the immune system, while white fat has stronger plasticity to tissues The study also found that 101 proteins appear to be secreted only through brown fat Among them, one protein, epdr1, has attracted special attention of scientists Animal experiments show that epdr1 plays an important role in the development of brown fat cells "How brown fat is formed has always been a mystery, and now we have a clue." The study authors said The results of proteomic analysis revealed new potential targets (picture source: reference [1]) This list of protein molecules, undoubtedly, provides many clues for scientists to better understand the signals of fat, from which they may find new drug targets for obesity and other metabolic diseases [1] Atul Deshmukh et al., (2019) Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine Cell Metabolism DOI: https://doi.org/10.1016/j.cmet.2019.10.001
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