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Original title: Scientists have found that essential omega-3 fatty acids regulate the developing brain
necessary omega-3
fatty acids
(n-3 PUFA) are essential for the functional maturity of the brain. In epidemiological studies, mother intake of n-3 PUFA was associated with a reduction in multiple neurological disorders, but little was known about the lack of mechanisms affecting the development of the central nervous system.
Recently, researchers at
America
and
France
found that a deficiency of n-3 PUFA in the mother's
diet
alters the phagocytosis of developing hema synapses by activating a 12/15-lipooxygen (LOX)/12-HETE signal conduction path, thereby altering the phagocytosis of the developing hema synapse element glial cells, thereby altering the cognitive morphology of future generations. The article is entitled:
omega
-3 fatty acids tune microglial phagocytosis of synaptic elements in the developmenting brain.
Active small glial cells devour synactosomes are an important process of normal brain development, and once the neuron circuit is established, small glial cells can help improve synact connections by devouring the synapses in the early post-birth period by sublinking proteins and complement cascading dependence. The refinement of synapses is a sign of a variety of neurodevelopmental disorders. The researchers found that n-3 PUFA deficiency in the maternal diet activates a 12/ 15-liposome (LOX)/12-HETE signaling path, alters the small glial cell ideotype, impairs the steady-state signal in the small glial cell body, enhances its phagocytosis activity, leads to synapse refinement and loss, affects the formation of neuron circuits, alters the morphology of the methane neurons and the space work memory of the sea horse. This shows that the activity of small glial cells can be improved through specific dietary strategies and is an effective way to prevent and treat neurological development disorders.
paper link: