echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > Scientists have found that secreted proteins help with muscle repair and growth

    Scientists have found that secreted proteins help with muscle repair and growth

    • Last Update: 2023-02-01
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
          

       

    Image: PDGF-B secreted by skeletal muscle cells not only promotes cell proliferation, but also promotes muscle hypertrophy with contractile function
    .

    Source: Tokyo Metropolitan University

    Scientists at Tokyo Metropolitan University have discovered that a protein called platelet-derived growth factor B sub-(PDGF-B) is continuously secreted from skeletal muscle cells and helps repair muscle by encouraging myoblasts (muscle
    stem cells) to proliferate.
    Unexpectedly, they found that PDGF-B also helps with the growth
    of muscle fibers.
    They confirmed that this corresponded
    to stronger fiber shrinkage.
    Their findings provide game-changing therapies
    for the treatment of muscle wasting and injury.

    Saratine is a small protein
    secreted by skeletal muscle cells.
    They have a wide range of functions and can act on cells
    near or far from where they are generated.
    The full picture of how muscle factors affect cellular processes is far from clear, but it is believed that they play an important role in exercise-related bodily functions, particularly the maintenance of
    muscle tissue.

    A team led by Yasuko Manabe, an associate professor at Tokyo Metropolitan University, has been studying how muscle factors affect the behavior of
    muscle cells.
    Through numerous experiments, they found that a muscle factor called platelet-derived growth factor sub-B (PDGF-B) is secreted by skeletal muscle in a constitutive way, i.
    e.
    , without any stimulation
    .
    To understand the role played by PDGF-B, they extracted myoblasts, precursor cells that continue to differentiate into muscle fibers, and exposed them to
    PDGF-B.
    They were able to clearly show that PDGF-B induced greater proliferation of myoblasts
    .

    Strangely, they also found that PDGF-B affects cells
    that have already differentiated.
    They remove the myotubes (the developmental stages of muscle fibers) and expose them to
    the same sarcosine.
    The myotube treated with this method shows pronounced maturation under the microscope with a marked increase
    in diameter.
    They also expressed more myosin heavy chains, a key part of the myosin protein structure, the molecular motor
    responsible for muscle contraction.
    Using a recently developed technique based on observing how the myotube responds to electrical impulses, this has been shown to directly correspond to increased contraction strength
    .
    Therefore, PDGF-B not only helps make more muscle, but also makes them
    stronger.
    But this does not mean that both processes are accelerated at will
    .
    They noted subtle differences in the PDGF-B signaling pathway between myotubes and myoblasts; The team believes that these differences may be related to
    the shift of cells from the proliferation stage to the mature stage.

    The team's work clearly shows that PDGF-B is involved in muscle regeneration and is a big step
    forward in developing effective treatments for muscle injury and atrophy, as well as protocols to improve muscle performance.

    This work was supported
    by the Japan Association for the Promotion of Science (JSPS) KAKENHI Scientific Research Grant [grant numbers JP 17H02159, JP 26242068 and 18H04086], the Next Generation World-Leading Researchers Science Grant Promotion Program [JSPS Next Project No.
    LS102], the University of Tokyo Innovation Research Project Strategic Research Fund, and the Tokyo Metropolitan Government Advanced Research Grant [RR -2].

    Article: PDGF-B secreted from skeletal muscle enhances myoblast proliferation and myotube maturation via activation of the PDGFR signaling cascade


    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.